Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer

Drugs & Aging
J Andrew Skirvin, S M Lichtman

Abstract

Persons over the age of 65 years are the fastest growing segment of the US population. In the next 30 years they will comprise over 20% of the population. Fifty per cent of all cancers occur in this age group and therefore there will be an expected rise in the total cancer burden. There has been an increasing trend over the past 20 years toward the use of oral chemotherapy. This change has been encouraged by the need to decrease the costs of chemotherapy administration, patient preferences and quality of life issues. Factors that must be considered with oral chemotherapy administration include limitations of saturability of absorption, patient compliance and pharmacokinetic/pharmacodynamic changes which occur in elderly patients. Interpatient variability and drug metabolism, particularly age-related changes in drug metabolism are being studied. The cytochrome P450 system has been intensively studied because of its importance with regard to chemotherapeutic drugs. This article reviews these issues and provides details regarding specific drugs including temozolomide, thalidomide, topotecan, the fluoropyrimidines, etoposide, hydroxycarbamide (hydroxyurea), tamoxifen, and alkylating drugs. Complementary and alternative therapies ar...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·N TumerD T Lowenthal
May 1, 1992·Age and Ageing·S M LichtmanJ Lovecchio
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·Y BécouarnA Ravaud
Apr 28, 1990·Lancet·I S FentimanM S Aapro
Jan 1, 1990·Cancer·A H LebovitsM R Messe
Feb 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L RichardsonA M Levine
Feb 1, 1990·Journal of the American Geriatrics Society·J S Black, W Kapoor
Sep 1, 1989·Journal of the American Geriatrics Society·P W Robie
Sep 1, 1989·Journal of the American Geriatrics Society·P Barry, P R Katz
Nov 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L RichardsonA Levine
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D O DixonH E Wilson
Sep 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M LevineC A Johnson
Jun 27, 1986·JAMA : the Journal of the American Medical Association·J SametJ S Goodwin
Jan 1, 1971·Gerontologia·H TauchiJ Okutomi
Oct 2, 1971·Die Medizinische Welt·G Weiser, J Zelger
Sep 1, 1970·Metabolism: Clinical and Experimental·G B Forbes, J C Reina
Apr 1, 1984·The American Journal of Medicine·W J HrusheskyB J Kennedy
Feb 1, 1984·Journal of the American Geriatrics Society·D L Schmucker
Jan 1, 1981·The New England Journal of Medicine·G Bonadonna, P Valagussa
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Giovanazzi-BannonA B Benson
Feb 1, 1994·The Surgical Clinics of North America·B M EversJ C Thompson
Jun 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G MilanoF Demard
Jan 15, 1994·Annals of Internal Medicine·W A Satariano, D R Ragland
Mar 1, 1993·British Journal of Cancer·C R LeeA A Deshmukh
Oct 6, 1993·Journal of the National Cancer Institute·P A Newcomb, P P Carbone
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K R HandeD H Johnson
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M O'ReillyP Lewis
Apr 1, 1996·Journal of the American Geriatrics Society·S M LichtmanV Vinciguerra
Dec 1, 1995·British Journal of Clinical Pharmacology·K T KivistöM Eichelbaum
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G LiuE Warner
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E S NewlandsP G Richards
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·H Kastrissios, T F Blaschke

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Citations

Nov 11, 2003·Critical Reviews in Oncology/hematology·Brigitte TranchandGilles Freyer
Nov 11, 2003·Critical Reviews in Oncology/hematology·Deborah McCaffrey Boyle
Aug 14, 2003·Experimental Gerontology·Klaus Turnheim
Jun 2, 2005·Nature Reviews. Cancer·Samir D UndeviaMark J Ratain
Jul 25, 2012·Nature Reviews. Clinical Oncology·Supriya MohileArti Hurria
Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y F LiJ J Kavanagh
Feb 27, 2007·BMJ : British Medical Journal·Sandeep D Parsad, Mark J Ratain
Jul 24, 2003·Drugs & Aging·Veena JohnStuart Lichtman
May 17, 2007·Drugs & Aging·Sara LonardiSilvio Monfardini
Nov 11, 2003·Clinical Pharmacokinetics·Hans WildiersAllan T van Oosterom
May 14, 2004·Clinical Pharmacokinetics·Giuseppe ToffoliMauro Boiocchi
Nov 19, 2010·Bioanalysis·Dylan M BachWilliam Clarke
Feb 4, 2016·Indian Journal of Cancer·Vanita NaronhaKumar Prabhash
May 24, 2011·Seminars in Oncology·Abdo Haddad, Dale Shepard
Dec 16, 2005·Clinical Lung Cancer·Jennifer GarstJeffrey Crawford
Jun 17, 2008·Critical Reviews in Oncology/hematology·Christèle Blanc-BissonIsabelle Bourdel-Marchasson
Dec 8, 2004·Experimental Gerontology·Klaus Turnheim
May 5, 2004·The Urologic Clinics of North America·Tomasz M Beer, Joseph S Bubalo
Feb 23, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefano BarbieriPaolo Colombo
Jan 11, 2005·Clinical Journal of Oncology Nursing·Jaime M Green, Eileen Danaher Hacker
Dec 18, 2009·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Torsten Hoppe-Tichy
May 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kari B WisinskiJill M Kolesar
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Christian AymannsDavid Czock
Jan 25, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Fengling WangWeidong Chen
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert J ten TijeSharyn D Baker
Apr 30, 2020·JAAPA : Official Journal of the American Academy of Physician Assistants·Lauren Robinson, Neena A Xavier
Dec 4, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Stuart M Lichtman
Jul 7, 2018·European Journal of Clinical Pharmacology·Teerachat SaehengJuntra Karbwang
Dec 12, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Bushra Salman, Murtadha Al-Khabori
Dec 6, 2020·Journal De Médecine Vasculaire·M SebuhyanD Farge

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