Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients.

European Journal of Clinical Pharmacology
Mustafa E IbrahimMelanie S Joy

Abstract

The ability to predict and detect clinical and subclinical nephrotoxicity early in the course of therapy has the potential to improve long-term outcomes in cancer patients receiving cisplatin chemotherapy. Pharmacokinetic parameters could serve as predictors of cisplatin-induced nephrotoxicity. Participants [n = 13] were treated with a 1-h cisplatin infusion [30-75 mg/m2]. Blood was collected pre-dose and up to 6 h post-dose. Urinary biomarkers [KIM-1, calbindin, clusterin, GST-pi, β2M, albumin, NGAL, osteopontin, clusterin, MCP-1, cystatin C, and TFF3] were measured at baseline, days 3 and 10. Total and unbound platinum concentrations were measured using ICP/MS. Noncompartmental analysis was performed, and correlation and regression analyses evaluated the relationships between platinum pharmacokinetics and nephrotoxicity. Peak platinum urinary concentrations correlated with urinary levels of KIM-1, calbindin, clusterin, GST-pi, β2M, albumin, NGAL, osteopontin, clusterin, cystatin C, and TFF3 at day 10. Unbound platinum plasma concentrations at 2 h also correlated with urinary clusterin, β2M, cystatin C, NGAL, osteopontin, and TFF3 at day 3. Regression analyses suggested 2-h total plasma platinum concentrations greater than 200...Continue Reading

References

Aug 1, 1978·The American Journal of Medicine·N E Madias, J T Harrington
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·L J van WarmerdamJ H Beijnen
Oct 16, 2001·European Journal of Clinical Pharmacology·B ErdlenbruchM Lakomek
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Oct 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael HaaseUNKNOWN NGAL Meta-analysis Investigator Group
Nov 4, 2010·Advances in Chronic Kidney Disease·Prasad Devarajan
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Sep 26, 2012·Nature Reviews. Nephrology·Michael HaaseClaudio Ronco

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Citations

Mar 7, 2020·International Journal of Preventive Medicine·Mohammad Reza TamadonRaheb Ghorbani
Oct 5, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anissa MoktefiChristophe Tournigand
Feb 9, 2021·Critical Reviews in Clinical Laboratory Sciences·Yumeng Wen, Chirag R Parikh
Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng
Feb 19, 2021·Journal of Clinical Pharmacology·Asaf LebelBradley L Urquhart

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Methods Mentioned

BETA
blood collection

Software Mentioned

Phoenix®
SAS®

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