Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM).

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Apurva R PatelMandip Singh

Abstract

3,3'-Diindolylmethane (DIM) is the major in vivo product of the acid-catalyzed oligomerization of indole-3-carbinol present in cruciferous vegetables. 1, 1-bis (3'-indolyl)-1-(p-substituted phenyl) methanes [C-substituted diindolylmethanes (C-DIMs)] are a new class of anticancer compounds derived from indole 3-carbinol. Despite rapidly increasing knowledge regarding mechanisms responsible for the chemopreventive properties of DIM-C-pPhC6H5, there have been relatively few studies determining the absorption and pharmacokinetic properties of DIM-C-pPhC6H5 to explore its clinical utility. In this study, we assessed the solubility, lipophilicity and Caco-2 cell permeability of methylene-substituted DIM. Pharmacokinetic properties in rats were determined following i.v. and oral administration of a novel analog of DIM. Pharmacokinetic parameters were determined using non-compartmental and compartmental techniques with WinNonlin® 5.0 software. To explore potential In Vitro-In Vivo Correlation (IVIVC) between the in vitro permeability values, and the oral absorption pharmacokinetics, we employed deconvolution of i.v. and oral data using a three compartment Exact Loo-Riegelman method. The oral absorption and disposition were described by...Continue Reading

References

Jul 6, 2000·International Journal of Pharmaceutics·R Panchagnula, N S Thomas
May 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mark J AndertonDonald E Mager
Aug 12, 2004·The Prostate·Maya Nachshon-KedmiShmuel Yannai
Apr 6, 2006·The AAPS Journal·Praveen V BalimaneSaeho Chong
Aug 8, 2006·Journal of Pharmacological and Toxicological Methods·Roula Konsoula, Frank A Barile
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·J L DavisM G Papich
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory A ReedAryeh Hurwitz
Nov 1, 2007·Nature Reviews. Drug Discovery·Paul D Leeson, Brian Springthorpe
Jan 11, 2008·Pharmaceutical Research·Xiaoxi ChenPraveen V Balimane
May 27, 2008·Cancer Letters·Stephen SafeSudhakar Chintharlapalli
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory A ReedAryeh Hurwitz
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nkechi IchiteMandip Singh
Jun 1, 2010·Burns : Journal of the International Society for Burn Injuries·Susumu YamashitaTae-Hyung Han
Oct 28, 2010·Molecular Cancer Therapeutics·Nkechi IchiteMandip Singh

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Citations

May 29, 2014·Pharmaceutical Research·Apurva R PatelMandip Singh
Jul 3, 2015·Drug Development and Industrial Pharmacy·Ignacio González-GarcíaMarival Bermejo
Jun 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Apurva R PatelMandip Singh
Dec 21, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Apurva R PatelMandip Singh
Dec 21, 2018·Archives of Toxicology·Timothy E HoffmanWilliam H Hanneman
Dec 8, 2021·Biomedical Chromatography : BMC·Alexander P LakeevIgor N Kuznetsov

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