Pharmacokinetic examination of p-aminobenzoic acid passage through the placenta and the small intestine in rats

Journal of Drug Targeting
F StaudM Láznícek

Abstract

In the present study the permeability of the rat small intestine and the placenta to p-aminobenzoic acid (PABA) and antipyrine (AP) was investigated. Perfusion of the rat term placenta was used to determine the materno-fetal transfer of both compounds. PABA appeared in the fetal compartment faster than AP (ktransfer = 0.064 and 0.046 min-1, respectively). The rate of equilibration between the maternal and fetal compartments and placental clearance were lower for PABA than for AP (kequilibration = 0.011 and 0.020 min-1; Clp = 0.22 and 0.33 ml/min, respectively); the feto-maternal concentration ratios at equilibrium (FMCReq) were, however, mutually comparable. Similarly, PABA proved to be absorbed from the small intestine significantly faster than AP (ka = 0.824 min-1 and 0.479 min-1; tmax = 3.1 min and 8.9 min, respectively). The apparent volume of distribution (Vd) of AP in non-pregnant animals showed that the drug is distributed into the whole body water as expected (Vd = 0.66 l/kg); however, Vd of AP in pregnant animals was estimated to be 1.81 l/kg. Vd of PABA in non-pregnant animals showed its partially limited distribution, which was only slightly increased in the pregnant animals. Our results confirmed a faster penetratio...Continue Reading

References

May 1, 1977·Clinical Pharmacokinetics·B Krauer, F Krauer
Jan 1, 1979·Scandinavian Journal of Plastic and Reconstructive Surgery·D M Davies
Jan 1, 1986·European Journal of Clinical Pharmacology·M Láznícek, K E Senius
Jan 1, 1981·International Journal of Health Services : Planning, Administration, Evaluation·R H Elling

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Citations

Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·F StaudP Pávek

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