PMID: 8585108Oct 1, 1995Paper

Pharmacokinetic interaction between lansoprazole and theophylline

Therapeutic Drug Monitoring
G R GrannemanJ H Cavanaugh

Abstract

The pharmacokinetic interaction potential of the new proton-pump inhibitor lansoprazole and theophylline was assessed in a double-blind, two-period (13-day duration per period), multiple-dose crossover study in 14 healthy male volunteers. Lansoprazole 60 mg or placebo once daily was coadministered with anhydrous theophylline 200 mg four times daily. Plasma theophylline concentrations were quantitated via high-performance liquid chromatography. Lansoprazole did not appear to affect substantially the absorption profile or clearance of theophylline. Theophylline area under the plasma concentration-versus-time curve over the 6-h dosing interval decreased slightly (13%) but statistically significantly during lansoprazole coadministration. As the magnitude of this effect was small, this interaction is likely to be clinically insignificant.

Citations

Mar 29, 2000·Alimentary Pharmacology & Therapeutics·W J PanR H Hunt
Mar 10, 2000·Journal of Clinical Pharmacology·M D KarolJ H Cavanaugh
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Stephen Brett
May 6, 2005·Clinical Pharmacokinetics·Catherine LitalienChristophe Faure
Jul 9, 2010·Clinical Pharmacokinetics·Ryuichi Ogawa, Hirotoshi Echizen
Feb 20, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ralph-Steven Wedemeyer, Henning Blume
Dec 16, 2003·Research in Veterinary Science·J VelíkL Skálová
Sep 2, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Henning BlumeBarbara S Schug
Mar 16, 2001·Expert Opinion on Pharmacotherapy·K G TolmanJ C Fang
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·L B Gerson, G Triadafilopoulos
Apr 20, 2000·The Annals of Pharmacotherapy·M P PaiG W Amsden
Oct 6, 1999·British Journal of Clinical Pharmacology·K DilgerU Klotz

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