PMID: 8971674Dec 1, 1996Paper

Pharmacokinetic interactions between repeated dose phenylbutazone and gentamicin in the horse

Journal of Veterinary Pharmacology and Therapeutics
T WhittemK Turner

Abstract

This study examined the pharmacokinetics of steady-state phenylbutazone and single bolus intravenous gentamicin when administered together in the horse. The trial design was completed as a cross-over with seven thoroughbred horses. In the first phase each horse received 2.2 mg/kg gentamicin intravenously. After a 2-week washout, each horse received 4.4 mg/kg phenylbutazone intravenously every 24 h for 5 days. On the fourth day each horse received gentamicin as before. Plasma was harvested for gentamicin concentration determination by fluorescence polarization immunoassay and for phenylbutazone concentration determination by high-performance liquid chromatography. All gentamicin data were best approximated by a two-compartment open model using sequential, weighted non-linear regression. Pharmacokinetic parameters were calculated using model-dependent formulae. Phenylbutazone data were analysed by non-compartmental methods. Phenylbutazone induced a 49% increase in the rate of gentamicin return to the central compartment from peripheral tissues (k21) (P < 0.05) and there was a trend to a 24% increase in k12 (P = 0.052). The gentamicin elimination half-life was decreased 23% and the Vd(urea) was reduced by 26%. No induction by gent...Continue Reading

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Citations

Feb 22, 2005·Journal of Veterinary Pharmacology and Therapeutics·P K SidhuP Lees
Jan 12, 2012·Journal of Veterinary Pharmacology and Therapeutics·S CoxT Doherty
Apr 27, 2007·Experimental Animals·Tomoe Ogino, Toshiro Arai
Aug 23, 2005·American Journal of Veterinary Research·Tomoe OginoYoshiyuki Takahashi
Oct 2, 2015·Journal of Veterinary Internal Medicine·J R BauquierR D Nolen-Walston
Oct 3, 2002·Equine Veterinary Journal·A SteinmanS Soback

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