PMID: 17460352Apr 27, 2007Paper

Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice

Experimental Animals
Tomoe Ogino, Toshiro Arai


We examined the pharmacokinetic interactions of enrofloxacin and flunixin in male ICR mice that were subcutaneously (SC) administered with both or either one of the drugs. The experiments were performed on the following three groups: flunixin alone (2 mg/kg, SC), combination of flunixin (2 mg/kg, SC) and enrofloxacin (10 mg/kg, SC), and enrofloxacin alone (10 mg/kg, SC). Blood samples were collected at 5, 15 and 30 min, and 1, 2, 3, 4, 5 and 6 h after the drug administration, and the pharmacokinetic parameters of flunixin and enrofloxacin were evaluated from the plasma drug concentrations. Significant changes were detected in the pharmacokinetics of flunixin following its coadministration with enrofloxacin. Coadministration of flunixin and enrofloxacin resulted in a 41% increase of the area under the curve (AUC) and a 53% extension of the terminal half-life of flunixin; moreover, flunixin attained the maximum plasma drug concentration 2.75 times faster than when administered alone. The terminal rate constant and the maximum plasma drug concentration showed significant decreases of 34% and 33%, respectively, following the coadministration of enrofloxacin and flunixin as compared to those following the administration of flunixin ...Continue Reading


Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Pyörälä
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·T WhittemK Turner
Sep 26, 1997·Antimicrobial Agents and Chemotherapy·P C HannanM Stegemann
Jan 7, 2004·Journal of Microbiological Methods·Séverine TaskerMichael R Lappin
Aug 23, 2005·American Journal of Veterinary Research·Tomoe OginoYoshiyuki Takahashi
Dec 14, 2005·Journal of Veterinary Pharmacology and Therapeutics·N L RegmiM Shimoda

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