Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis

Annals of Tropical Medicine and Parasitology
K PengsaaA Subchareon

Abstract

The pharmacokinetics of albendazole/albendazole sulphoxide and praziquantel were investigated in Thai children with Giardia infection. Twenty school-age children were randomly allocated to receive either a single oral dose of albendazole (400 mg/child) or the same dose of albendazole given concurrently with a single oral dose of praziquantel (20 mg/kg). The concentrations of albendazole/albendazole sulphoxide and praziquantel in plasma samples, collected at intervals in the first 24 h post-treatment, were then quantified using HPLC with ultra-violet detection. No significant pharmacokinetic interaction between the albendazole and praziquantel was demonstrated. For albendazole sulphoxide, the active metabolite of albendazole, there was marked inter-individual variation in the maximum plasma concentration and the 'area under the curve'. The pharmacokinetics of albendazole sulphoxide were similar whether albendazole was given alone or in combination with praziquantel.

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Citations

Nov 8, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Na-BangchangJ Lazdins
Jan 9, 2001·Clinical Microbiology Reviews·T B Gardner, D R Hill
Oct 26, 2012·Tropical Medicine and Health·Rapeepun PrasertbunSupaluk Popruk
Mar 15, 2011·British Journal of Clinical Pharmacology·Renata Monteiro LimaVera Lucia Lanchote
Feb 22, 2011·British Journal of Clinical Pharmacology·Hector H GarciaUNKNOWN Cysticercosis Working Group in Peru
Nov 4, 2011·Malaria Journal·Soumita GhoshHaripalsingh M Sonawat
Mar 15, 2014·PLoS Neglected Tropical Diseases·Vinay PasupuletiAdrian V Hernandez
Jul 26, 2014·Expert Review of Anti-infective Therapy·Angel A EscobedoMaydel Alfonso

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