Abstract
In critically ill children, intraosseous (IO) administration of a medicine provides an alternate vascular access route when IV access is not readily available. We investigated the short and long-term efficacy and safety of a totally intraosseously implantable device. This study was undertaken in micropigs (i) to compare serum levels achieved by equal bolus dosages of two antibiotics (amikacin and vancomycin) administered through an intratibial needle, an intraosseous implantable device and central IV routes to determine whether standard parenteral dosing guidelines for antibiotics may be applied without modification for IO injection, and (ii) to show the efficiency of the implantable device over a prolonged period, as a permanent access to intraosseous space. The area under the plasma concentration time curves were similar for IV, intratibial and through the intraosseous implantable device, for intermittent administrations of amikacin and vancomycin, over a period of 6 months. However, vancomycin did not reach therapeutic levels via both IO routes. We did not find any alteration of amikacin and vancomycin pharmacokinetics over a period of 6 months using the implantable device. No complication occurred. Long-term administration ...Continue Reading
References
Nov 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R D WelchB M Hargis
Jan 1, 1991·Cancer Investigation·D D Von Hoff
Nov 1, 1991·Journal of Pediatric Orthopedics·R D GalpinT C Frewen
Jul 1, 1991·Annals of Emergency Medicine·W H Spivey
May 31, 1990·The New England Journal of Medicine·D H Fiser
Sep 1, 1990·The American Journal of Emergency Medicine·R Moscati, G P Moore
Aug 1, 1989·Annals of Emergency Medicine·D G JaimovichG R Peters
Oct 1, 1989·Annals of Emergency Medicine·J P OrlowskiJ M Gallagher
Nov 1, 1987·The Journal of Pediatrics·W H Spivey
Sep 1, 1985·Annals of Emergency Medicine·V A RosettiC Aprahamian
Mar 1, 1993·The Journal of Bone and Joint Surgery. American Volume·J A RibeiroD R Knapp
Oct 1, 1996·Annals of Emergency Medicine·K R BrickmanG Reynolds
Nov 1, 1996·Journal of Pediatric Surgery·I GünalD Gürer
Feb 1, 1997·The Journal of Trauma·M Waisman, D Waisman
Jun 1, 1997·Pediatric Emergency Care·R T FiserD H Fiser
Aug 1, 1997·The American Journal of the Medical Sciences·M FiallosA Idris
Apr 1, 1947·The Journal of Pediatrics·S HEINILDF TUDVAD
Citations
Oct 4, 2006·American Journal of Veterinary Research·Luis M Rubio-MartínezFidel San Román
Mar 2, 2006·Journal of the American Veterinary Medical Association·Luis M Rubio-Martínez, Antonio M Cruz
Dec 18, 2007·The American Journal of Emergency Medicine·Daniel D Von HoffLarry J Miller
May 13, 2010·Veterinary Surgery : VS·Russell A ParkerKen C Smith
Aug 19, 2007·The Annals of Pharmacotherapy·Marcia L BuckJefferson M Sesler
Jun 5, 2021·Journal of Bone and Joint Infection·Josephine Olsen KippMats Bue