Pharmacokinetic Model of the Transport of Fast-Acting Insulin From the Subcutaneous and Intradermal Spaces to Blood

Journal of Diabetes Science and Technology
Dayu LvMarc Breton

Abstract

Pharmacokinetic (PK) models describing the transport of insulin from the injection site to blood assist clinical decision making and are part of in silico platforms for developing and testing of insulin delivery strategies for treatment of patients with diabetes. The ability of these models to accurately describe all facets of the in vivo insulin transport is therefore critical for their application. Here, we propose a new model of fast-acting insulin analogs transport from the subcutaneous and intradermal spaces to blood that can accommodate clinically observed biphasic appearance and delayed clearance of injected insulin, 2 phenomena that are not captured by existing PK models. To develop the model we compare 9 insulin transport PK models which describe hypothetical insulin delivery pathways potentially capable of approximating biphasic appearance of exogenous insulin. The models are tested with respect to their ability to describe clinical data from 10 healthy volunteers which received 1 subcutaneous and 2 intradermal insulin injections on 3 different occasions. The optimal model, selected based on information and posterior identifiability criteria, assumes that insulin is delivered at the administrative site and is then tra...Continue Reading

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Citations

Jun 2, 2017·Journal of Diabetes Science and Technology·Enrique Campos-NáñezMarc D Breton
Feb 17, 2018·Journal of Diabetes Science and Technology·Roberto VisentinClaudio Cobelli
Jul 14, 2018·Journal of Diabetes Science and Technology·Katharina FritzenOliver Schnell
Dec 14, 2018·Journal of Diabetes Science and Technology·Ronald J PettisLutz Heinemann

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