Pharmacokinetic-pharmacodynamic integration and modelling of florfenicol in calves

Journal of Veterinary Pharmacology and Therapeutics
P K SidhuP Lees

Abstract

Florfenicol was administered subcutaneously to 10 calves at a dose of 40 mg/kg. Pharmacokinetic-pharmacodynamic (PK-PD) integration and modelling of the data were undertaken using a tissue cage model, which allowed comparison of microbial growth inhibition profiles in three fluids, serum, exudate and transudate. Terminal half-lives were relatively long, so that florfenicol concentrations were well maintained in all three fluids. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined in vitro for six strains each of the calf pneumonia pathogens, Mannhemia haemolytica and Pasteurella multocida. An PK-PD integration for three serum indices provided mean values for P. multocida and M. haemolytica, respectively, of 12.6 and 10.4 for Cmax /MIC, 183 and 152 h for AUC0-24 h /MIC and 78 and 76 h for T>MIC. Average florfenicol concentrations in serum exceeded 4 × MIC and 1.5 × MIC for the periods 0-24 and 48-72 h, respectively. Ex vivo growth inhibition curves for M. haemolytica and P. multocida demonstrated a rapid (with 8 h of exposure) and marked (6 log10 reduction in bacterial count or greater) killing response, suggesting a concentration-dependent killing action. During 24-h incubation periods,...Continue Reading

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Citations

Oct 17, 2014·Experimental Animals·Chun LiuYi-Xiang Shao
Aug 9, 2015·The Veterinary Clinics of North America. Food Animal Practice·Michael D Apley
Dec 30, 2017·American Journal of Veterinary Research·Christie C BalcombLisa A Tell
Mar 27, 2019·Journal of Veterinary Pharmacology and Therapeutics·Weixuan LanZhiqiang Wang
Apr 22, 2015·Journal of Veterinary Pharmacology and Therapeutics·Q ZhangX-L Xiao
Jun 11, 2016·Physical & Occupational Therapy in Pediatrics·Debra CameronHelene J Polatajko
Oct 1, 2019·Journal of Veterinary Science·Wanhe LuoShuyu Xie
Nov 21, 2020·Journal of Pharmaceutical Sciences·Federico KarpDiana A Estenoz
Oct 23, 2020·Journal of Veterinary Pharmacology and Therapeutics·Pierre-Louis ToutainJohn D Turnidge
Mar 3, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fan YangRonald E Baynes
Jan 29, 2020·Ecotoxicology and Environmental Safety·Chao HanWanyu Shi

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