PMID: 3770599Aug 1, 1986Paper

Pharmacokinetic profile of paraquat following intravenous administration to the rabbit

Forensic Science International : Synergy
K Yonemitsu

Abstract

Pharmacokinetic studies of paraquat in rabbits were performed using [methyl-14C]-paraquat. Plasma concentration of paraquat following i.v. administration to the rabbit was fitted to a 3-exponential function of pharmacokinetic analysis. Distribution and elimination were discussed on the basis of the 3-compartment open model system, which has a central and two peripheral compartments. Computer simulations of paraquat levels in each compartment indicated that the slow-uptake peripheral compartment contained a greater amount of paraquat than the central or the fast-uptake peripheral compartment. On the basis of the present results of the computer simulations in company with tissue distributions of paraquat reported by the other investigators, it is likely that the slow-uptake peripheral compartment contains the lung. In cases of paraquat-induced renal failures, the paraquat levels of the slow-uptake peripheral compartment were remarkably higher than in cases of normal renal functions. Histology of the rabbit tissues 7 days after i.v. administration of paraquat revealed that marked changes were observed only in the kidney, suggesting some renal failures induced by paraquat. In spite of the high concentration of paraquat, which was p...Continue Reading

References

Oct 20, 1975·Archives of Toxicology·J M DouzeR H Drost
Oct 1, 1974·The Journal of Pathology·P SmithJ M Kay
Jan 1, 1971·British Journal of Industrial Medicine·C Butler, J Kleinerman
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Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno

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Citations

Dec 3, 1998·Pharmacology & Toxicology·A M Mølck, C Friis
Apr 29, 2014·Drug and Chemical Toxicology·Züleyha Başçi, Gökhan Eraslan
Jan 1, 1990·Human & Experimental Toxicology·P HouzéJ M Scherrmann
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho

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