PMID: 109293Jun 1, 1979

Pharmacokinetic properties of thiopental in two patients treated for uncontrollable seizures

Epilepsia
J C CloydD Perrier

Abstract

Thiopental was administered for seizure control in 2 patients with uncontrollable seizures. Serum samples were collected from each patient and assayed for thiopental, and the resulting serum concentration--time data were analyzed pharmacokinetically. The biologic half-life in both patients was significantly longer than previously reported values. Based on the limited number of patients studied, it would appear that half-life and volume of distribution increase with the degree of obesity, while clearance remains unchanged. These pharmacokinetic characteristics would be worthy of consideration in cases where there may be prolonged use of thiopental, eg., for the control of uncontrollable seizures.

References

Jun 1, 1969·British Journal of Anaesthesia·N L Wulfsohn, C W Joshi
Jan 7, 1967·British Medical Journal·A S Brown, J M Horton

Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·D P CrankshawD J Morgan
Sep 12, 2009·Clinical Pharmacokinetics·Célia Lloret LinaresStéphane Mouly
Jul 1, 1993·European Journal of Drug Metabolism and Pharmacokinetics·P Le CorreR Le Verge
May 1, 1993·Journal of Pharmaceutical Sciences·H RussoH Maillols
Apr 6, 2005·Journal of Clinical Anesthesia·A Casati, Marta Putzu
Apr 1, 1986·Drug Intelligence & Clinical Pharmacy·W A WatsonJ D Puckett

Related Concepts

Late Post-Traumatic Seizures
Half-Life
Obesity
Non-epileptic Convulsion
Sodipental

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