PMID: 8995497Jan 1, 1996Paper

Pharmacokinetic studies of 13-cis-retinoic acid in pediatric patients with neuroblastoma following bone marrow transplantation

Cancer Chemotherapy and Pharmacology
A A KhanV I Avramis

Abstract

A phase I clinical trial of 13-cis-retinoic acid (cis-RA) was undertaken to determine the maximally tolerated dose (MTD) and pharmacokinetics (PK) of cis-RA following bone marrow transplantation (BMT) in children with high-risk neuroblastoma. Mean peak serum levels of cis-RA in 31 pediatric patients ranged from 4.9 to 8.9 microM following doses of 100-200 mg/m2 per day, divided into two doses every 12 h administered orally. The PK of cis-RA obeyed a single-compartment model following first-order absorption in the majority of patients. A linear increase in the mean peak serum levels and area under the time-concentration curve (AUC) with increasing dose was observed. The average half-lives of absorption and elimination were 1.0 and 5.8 h, respectively. At the MTD of 160 mg/m2 per day, the mean cis-RA peak serum concentration was 7.2 +/- 5.3 microM. AUC values were not altered significantly during a 2-week course of treatment or over a long period of multiple courses. Levels of trans-retinoic acid, a metabolite of cis-RA, remained low but were similar on days 1 and 14, whereas the 4-oxo-13-cis-RA metabolite had increased in 64% of patients by day 14. Peak serum cis-RA concentrations correlated with clinical toxicity as grade 3 to ...Continue Reading

Citations

Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·I GuzhovaL G Larsson
Dec 21, 2000·Current Oncology Reports·C P Reynolds
Jul 26, 2003·Cancer Letters·C Patrick ReynoldsBarry J Maurer
Aug 21, 2003·Cancer Treatment Reviews·E J Estlin, G J Veal
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P E LovatC P Redfern
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H IrvingC P Redfern
Sep 16, 2003·Journal of Pediatric Hematology/oncology·Yuki YuzaMitsuyoshi Urashima
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Margot BrickelmaierLeonid Gorelik
Oct 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gareth J VealAlan V Boddy
May 6, 2004·Pediatric Transplantation·C Patrick Reynolds
Oct 8, 2008·Pediatric Blood & Cancer·Aurélien MarabelleJustyna Kanold
Jul 27, 2010·Pediatric Blood & Cancer·Ingo NeumannMartin S Staege
Mar 26, 2002·Biochemical Pharmacology·Julie MarillGuy G Chabot
Jan 5, 2002·Hematology/oncology Clinics of North America·C P Reynolds, R S Lemons
Feb 13, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D ChamberyS Babajko
Sep 25, 2001·Journal of the American Academy of Dermatology·M LebwohlP McClelland
Sep 11, 2002·FEBS Letters·Jörgen BierauAndré B P van Kuilenburg
Aug 20, 2016·Cancer Chemotherapy and Pharmacology·Vikram GotaPurna Kurkure
Sep 29, 2020·Frontiers in Immunology·Kevin X Liu, Shweta Joshi
Dec 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine K Matthay
Oct 15, 2021·The Biochemical Journal·Botheina GhandourNadine Darwiche

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