PMID: 9004427Jan 1, 1996Paper

Pharmacokinetic studies of different echo-contrast agents in the cerebral circulation of dogs

Ultrasound in Medicine & Biology
G SeidelM Kaps

Abstract

Ultrasound contrast agents (UCAs) are improving the signal-to-noise ratio of the reflected ultrasound so that Doppler frequency spectra can be recorded even under poor sonographic conditions. This is of particular diagnostic value in transcranial Doppler sonography. Depending on specific pharmacologic properties, echo-contrast agents may cause different increase and duration in Doppler signal amplitude. We used a dog model to study the temporal profile of Doppler signal amplitude after application of a phospholipid-containing echo-contrast agent (BY 963). In addition, we compared it with a contrast agent containing albumin (Albunex). Spherosome suspension BY 963 resulted in a dose-dependent increase in the duration of ultrasound amplification (Doppler enhancement of 1 mL, 3 mL and 10 mL of BY 963 per animal: 62.4 +/- 8.4, 72.8 +/- 9.2 and 67.7 +/- 4.2 s, respectively, n = 6). Detection of BY 963 in the extracranial jugular vein demonstrated that the UCA passes through the cerebral microcirculation (cerebral transit time was 2.2 +/- 0.2 s, n = 4). The signal enhancement lasted longer using the spherosome suspension compared with the albumin-containing solution (77.2 +/- 11.6 and 31.1 +/- 3.7 s, respectively, n = 6), and the maxi...Continue Reading

References

Nov 1, 1990·Stroke; a Journal of Cerebral Circulation·J H Halsey
Jan 1, 1989·Ultrasound in Medicine & Biology·J Ophir, K J Parker
Sep 1, 1968·Investigative Radiology·R Gramiak, P M Shah
Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·M KapsW Wurst
Feb 1, 1995·Stroke; a Journal of Cerebral Circulation·S OtisR Boyajian
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·F RiesR Schlief
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Jan 1, 1993·Ultrasound in Medicine & Biology·N de JongJ R Roelandt
May 1, 1993·Stroke; a Journal of Cerebral Circulation·U BogdahnW Hassel

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Citations

Apr 27, 2000·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·R UchimotoM Bräutigam
Jul 22, 1999·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·G SeidelM Kaps
Jul 21, 2001·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·M KapsA Broillet
Jun 25, 2004·Lasers in Surgery and Medicine·Tibo GerrietsErnst G Kraatz
Feb 12, 2019·Kidney Cancer·Tim J van OostenbruggePeter F A Mulders
Jul 17, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·G SeidelM Kaps
Apr 29, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·G SeidelM Kaps

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