Pharmacokinetic Studies of Factor VIII in Chinese Boys with Severe Hemophilia A: A Single-Center Study

Chinese Medical Journal
Zhen-Ping ChenR Wu

Abstract

Although much attention has been paid to the pharmacokinetics (PKs) of different factor VIII (FVIII) concentrates in persons with hemophilia A (HA), limited information is available in young boys with severe HA. In this study, we aimed to assess the PK parameters of FVIII products in boys with severe HA in China. A total of 36 boys (plasma-derived [pd]-FVIII, n = 15; recombinant [r] FVIII, n = 21) were enrolled between January 2015 and May 2016 in Beijing Children's Hospital. PK characteristics of FVIII products were studied according to a reduced 4-sampling time point design (1 h, 9 h, 24 h, and 48 h postinfusion). The mean FVIII half-life (t1/2) was 10.99 ± 3.45 h (range 5.52-20.02 h), the mean in vivo recovery (IVR) was 2.01 ± 0.42 IU/dl per IU/kg (range 1.24-3.02 IU/dl per IU/kg) and mean clearance (CL) of FVIII is 4.34 ± 1.58 ml·kg-1·h-1 (range 2.29-7.90 ml·kg-1·h-1). We also analyzed the influence of several parameters that potentially modulate FVIII PK. The age was closely associated with FVIII half-life (R2 = 0.32, P < 0.01). The t1/2of FVIII increased by 0.59 h per year. Besides age, von Willebrand factor antigen (VWF:Ag) also was associated with FVIII half-life (R2 = 0.52, P < 0.01). Patients with blood Group O had a ...Continue Reading

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Citations

Jul 1, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Peter L TurecekUNKNOWN iPATH study group
Oct 1, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Kun HuangRunhui Wu
Jul 12, 2019·Research and Practice in Thrombosis and Haemostasis·Pratima ChowdaryElena Santagostino
May 21, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Kun HuangRunhui Wu

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Methods Mentioned

BETA
blood draws

Software Mentioned

JMP13
WinNonlin

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