Pharmacokinetic study of p-coumaric acid in mouse after oral administration of extract of Ananas comosus L. leaves.

Biomedical Chromatography : BMC
Zhen MengLi-Jun Du

Abstract

Quantification of p-coumaric acid in mouse plasma following oral administration of Ananas comosus L. leaves was achieved by reversed-phase high-performance liquid chromatography using a mobile phase of water-acetonitrile (82:18, v/v) and UV detection at 310 nm. The method was linear (determination coefficient, r2 = 0.9997) within the tested range (0.04-1.28 microg/mL). Intra- and inter-day precision coefficients of variation and accuracy bias were acceptable (maximal CV value was 4.06% for intra-day and 4.19% for inter-day) over the entire range. The recoveries were 90.63, 97.98 and 100.01% for concentrations of 0.04, 0.32 and 1.28 microg/mL, respectively. This is a very rapid, sensitive and economical way to determine p-coumaric acid concentration in mouse plasma after oral administration of A. comosus leaves. The concentration-time curve was fitted to the one-compartment model. This is the first time that p-coumaric acid extracted from A. comosus leaves was detected by HPLC-UV method and its pharmacokinetic characteristic was comprehensively studied.

References

May 19, 2000·Experimental Gerontology·P D ReavenJ L Witztumc
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Mar 6, 2003·Journal of Agricultural and Food Chemistry·R CaiM Jalaluddin
Oct 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fan LeiLi-Jun Du
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Yutaka KonishiEiji Yoshioka
Jan 28, 2005·The American Journal of Chinese Medicine·Yu Nan ZhaoLijun Du
Feb 11, 2005·Journal of Chromatography. a·Su TianHiroshi Kayahara

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Citations

Sep 10, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Weidong XieLijun Du
Apr 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jun HuLijun Du
Mar 20, 2015·International Journal of Analytical Chemistry·Ramadoss KarthikeyanPuttagunta Srinivasa Babu
May 15, 2018·Critical Reviews in Analytical Chemistry·Paula Scanavez FerreiraMarlus Chorilli
Dec 23, 2015·Journal of the Science of Food and Agriculture·Kehan PeiShiyi Ou

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