Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats

Drug Development and Industrial Pharmacy
Y LiA S C Chan

Abstract

Puerarin is a potential therapeutic agent for cardiovascular diseases. But its poor oral bioavailability restricts its clinical application. In present study, as an evaluation of a formulation to improve the bioavailability of the drug, puerarin and its phospholipid complex were given to rats by intragastrically (i.g.) administration to compare pharmacokinetic, tissue distribution, and excretion. Serum samples were obtained at designated times after a single oral dose of 400 mg/kg puerarin or its complex. Tissue samples (heart, liver, spleen, kidney, lung, and brain), urine, and feces were collected and analyzed by a sensitive and specific high performance liquid chromatography (HPLC) method after i.g. administration of puerarin or its phospholipid complex. Compartmental and non-compartmental analyses were applied to the serum concentration versus time data. Pharmacokinetic parameters were calculated using the 3P97 pharmacokinetic software package. An open two-compartment, first-order model was selected for pharmacokinetic modeling. The results showed that after i.g. administration of 400 mg/kg puerarin and its phospholipid complex (equivalent to 400 mg/kg of puerarin), the pharmacokinetic parameters of the two formulations wer...Continue Reading

References

Feb 1, 1995·Biological & Pharmaceutical Bulletin·T YasudaK Ohsawa
Oct 27, 1999·Biomedical Chromatography : BMC·J WuR Zhang

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Citations

Dec 8, 2009·Acta Pharmacologica Sinica·Xuan QinYuan Huang
Apr 11, 2014·International Journal of Biological Sciences·Yang LiuXiaoyu Xu
Mar 7, 2014·Canadian Journal of Physiology and Pharmacology·Heba M MahdyAmani E Khalifa
Nov 16, 2010·Drug Development and Industrial Pharmacy·Zhongbin WuJianming Chen
Feb 8, 2008·Journal of Pharmaceutical Sciences·Xiaodong Wang, Marilyn E Morris
Feb 2, 2010·Fitoterapia·Suchinda MalaivijitnondNathachit Limjunyawong
Nov 26, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jeevan K PrasainJ Michael Wyss
Jan 16, 2007·Biomedical Chromatography : BMC·Jeevan K PrasainJ Michael Wyss
Mar 13, 2014·International Journal of Pharmaceutics·Hewei LiYanjiang Qiao
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rongsheng E WangJianfeng Cai
Sep 30, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hyo-Rin JungHea-Young Cho
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui KongHuihua Qu
May 29, 2018·BMC Pharmacology & Toxicology·Tosapol AnukunwithayaPhisit Khemawoot
Feb 5, 2021·Designed Monomers and Polymers·Huiru WangYimin Song

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