Pharmacokinetic variability due to environmental differences

Translational and Clinical Pharmacology
Nick Holford

Abstract

This tutorial describes sources of pharmacokinetic variability that are not obviously linked to genetic differences. The sources of variability are therefore described as environmental. The major quantitative sources of environmental variability are body size (including body composition), maturation and organ function. Size should be considered in all patients. Maturation is mainly relevant to neonates and infants less than 2 years of age. Renal function is the most important predictable source of variability due to differences in organ function.

References

Nov 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G J Schwartz
Sep 24, 2005·Clinical Pharmacokinetics·Sarayut JanmahasatianBruce Green
Oct 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Malin M RhodinNick H G Holford
Aug 28, 2009·Paediatric Anaesthesia·Amanda L PottsSanna Vilo
Aug 17, 2010·British Journal of Anaesthesia·L I CortínezP Sepulveda
Feb 16, 2011·Paediatric Anaesthesia·Brian J Anderson, Nick H G Holford
Nov 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeannine S McCuneNicholas H G Holford
Dec 1, 2017·Translational and Clinical Pharmacology·Nick Holford

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Citations

Dec 1, 2018·Translational and Clinical Pharmacology·Nick Holford
Nov 25, 2020·Pharmacology Research & Perspectives·Stacey TannenbaumDonald Newgreen

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Methods Mentioned

BETA
PMA

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