Pharmacokinetic/Pharmacodynamic Correlation of Cefquinome Against Experimental Catheter-Associated Biofilm Infection Due to Staphylococcus aureus

Frontiers in Microbiology
Yu-Feng ZhouYa-Hong Liu

Abstract

Biofilm formations play an important role in Staphylococcus aureus pathogenesis and contribute to antibiotic treatment failures in biofilm-associated infections. The aim of this study was to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) profiles of cefquinome against an experimental catheter-related biofilm model due to S. aureus, including three clinical isolates and one non-clinical isolate. The minimal inhibitory concentration (MIC), minimal biofilm inhibitory concentration (MBIC), biofilm bactericidal concentration (BBC), minimal biofilm eradication concentration (MBEC) and biofilm prevention concentration (BPC) and in vitro time-kill curves of cefquinome were studied in both planktonic and biofilm cells of study S. aureus strains. The in vivo post-antibiotic effects (PAEs), PK profiles and efficacy of cefquinome were performed in the catheter-related biofilm infection model in murine. A sigmoid E max model was utilized to determine the PK/PD index that best described the dose-response profiles in the model. The MICs and MBICs of cefquinome for the four S. aureus strains were 0.5 and 16 μg/mL, respectively. The BBCs (32-64 μg/mL) and MBECs (64-256 μg/mL) of these study strains were much higher than their correspondin...Continue Reading

References

May 1, 1995·Antimicrobial Agents and Chemotherapy·J BlaserW Zimmerli
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·J G den HollanderJ W Mouton
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D Turnidge
May 21, 1999·Science·J W CostertonE P Greenberg
Jan 24, 2003·Infection and Immunity·Jagath L KadurugamuwaPamela R Contag
Feb 8, 2003·The Veterinary Journal·F Shojaee AliabadiP Lees
Sep 9, 2006·Veterinary Microbiology·Hui JinHuanchun Chen
Mar 19, 2008·Infection and Immunity·Kati SeidlMarkus Bischoff
Sep 28, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·O CirioniA Giacometti
Jun 26, 2012·International Journal of Antimicrobial Agents·Ana Fernández-OlmosRafael Cantón
Jul 17, 2012·The Journal of Antimicrobial Chemotherapy·Jorge Parra-RuizJosé Hernández-Quero
Oct 24, 2012·Antimicrobial Agents and Chemotherapy·Wang HengzhuangNiels Høiby
Dec 25, 2012·Chemistry & Biology·Hwang-Soo Joo, Michael Otto
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Jing WangZhenling Zeng
Apr 29, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M D MaciàA Oliver
Jul 30, 2014·Antimicrobial Agents and Chemotherapy·Qi ShanZhenling Zeng
Jan 17, 2015·BMC Veterinary Research·Mary Hellen Fabres-KleinAndrea de Oliveira Barros Ribon
Mar 18, 2015·Journal of Veterinary Pharmacology and Therapeutics·Y F ZhouY H Liu

❮ Previous
Next ❯

Citations

Oct 1, 2019·Journal of Veterinary Science·Wanhe LuoShuyu Xie

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Assay

Software Mentioned

WinNonlin

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.