Pharmacokinetic/pharmacodynamic evaluation of eslicarbazepine for the treatment of epilepsy

Expert Opinion on Drug Metabolism & Toxicology
Monika BanachStanisław J Czuczwar

Abstract

Eslicarbazepine acetate (ESL) is a novel antiepileptic drug registered as the adjunctive treatment of partial-onset seizures in adults. As a third-generation medication, ESL is believed to have favorable efficacy/safety profile and pharmacokinetic properties in comparison with related drugs (carbamazepine and oxcarbazepine). The aim of the paper was to evaluate pharmacodynamic and pharmacokinetic properties of ESL with aspect to epilepsy treatment. The review of the scientific literature was based on the PubMed database, Clinical Trials, FDA and European Medicines Agency websites to elicit current information on drug metabolism, mechanism of action and efficacy/safety profile. Results of clinical trials indicate that ESL possessed a favorable profile of anticonvulsant efficacy and tolerability as an add-on therapy in adult patients at daily doses of 800 and 1200 mg. Pediatric trials are in progress and their results will allow to characterize a role of ESL in the treatment of epilepsy in children.

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Citations

Mar 22, 2016·Expert Opinion on Pharmacotherapy·Jaime GierboliniSelim R Benbadis
May 6, 2016·Expert Opinion on Pharmacotherapy·Johan Zelano, Elinor Ben-Menachem
Apr 5, 2018·Paediatric Drugs·Alexis ArzimanoglouUNKNOWN Pediatric Epilepsy Academic Consortium for Extrapolation (PEACE)

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