Pharmacokinetics after subcutaneous administration of a single dose of cefovecin sodium in African lions (Panthera leo)

American Journal of Veterinary Research
Kelly P FlaminioSumeia Mohammed Mohammed

Abstract

OBJECTIVE To determine the pharmacokinetics of cefovecin sodium after SC administration of a single dose to African lions (Panthera leo). ANIMALS 3 adult (9 to 10 years old; 1 male and 2 females) and 3 juvenile (2 years old; 1 male and 2 females) African lions. PROCEDURES A crossover study was conducted. A single dose of cefovecin was administered SC at 4 mg/kg (half dose) and 8 mg/kg (full dose) to African lions. Blood samples were collected daily for 14 days after cefovecin injection. Plasma drug concentrations were determined by use of high-performance liquid chromatography with UV detection. RESULTS Cefovecin had first-order elimination kinetics for doses of 4 and 8 mg/kg. Mean ± SD maximum plasma concentration was 9.73 ± 1.01 μg/mL and 18.35 ± 0.94 μg/mL after doses of 4 and 8 mg/kg, respectively. Time to maximum plasma concentration was approximately 4 hours for both doses. Mean elimination half-life was approximately 111 and 115 hours after doses of 4 and 8 mg/kg, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Cefovecin was detected in lion plasma for 336 hours after administration at both 4 and 8 mg/kg at concentrations greater than the reported minimum inhibitory concentration (0.06 μg/mL) for common bacterial organi...Continue Reading

References

Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M R StegemannS Blanchflower
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M R StegemannS Blanchflower
Apr 22, 2008·The Journal of Small Animal Practice·C A PassmoreM R Stegemann
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·L R ThuesenM T Skaanild
Feb 18, 2011·Journal of Veterinary Pharmacology and Therapeutics·J BakkerM F Bertelsen
Jul 12, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Gabby M SchraderSandra R Black
Oct 23, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·James SteeilKaren Tobias
Mar 8, 2013·Anaerobe·Rodrigo Otávio Silveira SilvaFrancisco Carlos Faria Lobato
Sep 26, 2014·American Journal of Veterinary Research·Giordano NardiniAnna Zaghini
Nov 20, 2014·Journal of Veterinary Pharmacology and Therapeutics·S CoxT Doherty
Jan 4, 2018·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Andrew C CushingSherry Cox

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Citations

Mar 30, 2021·Journal of Veterinary Pharmacology and Therapeutics·Jennifer H YuSuzan Murray
Aug 25, 2021·ILAR Journal·Elizabeth A FalendyszJonathan M Sleeman

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