PMID: 2109643Apr 1, 1990Paper

Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man

Biopharmaceutics & Drug Disposition
W MartinJ Augustin

Abstract

The lysine salt of d,l-2-(4-isobutylphenyl)-propionic acid (ibuprofen lysine) was administered as a single oral dose of 500 mg by means of commercially available coated tablets (Imbun).* To assess the absolute bioavailability of ibuprofen after its oral application as a lysine salt, intravenous injections of ibuprofen solutions containing 200 mg and 400 mg of the drug served as reference application. In a partially randomized cross-over design, 8 healthy male volunteers received three different single dose administrations which were separated by wash-out periods of 4 days each. Ibuprofen plasma concentrations were determined by HPLC using direct injection, pre-column enrichment and column switching techniques. From the results of intravenous injections one can deduce linear ibuprofen pharmacokinetics within the considered dosage range, with corresponding AUC0-infinity values of 3786 micrograms * min ml-1 and 7260 micrograms * min ml-1 for the 200 mg and 400 mg doses, respectively. The values of plasma clearances as well as those of different volumes of distribution showed remarkable constancy after evaluation from both intravenous injections. The absorption of orally administered ibuprofen lysine proved to be rapid, resulting i...Continue Reading

References

Jul 13, 1984·The American Journal of Medicine·K S Albert, C M Gernaat
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Citations

Apr 10, 2004·International Journal of Pharmaceutics·Luma BaydounChristel C Müller-Goymann
Oct 16, 2003·International Journal of Pharmaceutics·Patrizia SantiPaolo Colombo
Oct 27, 2001·British Journal of Clinical Pharmacology·J LötschG Geisslinger
Sep 8, 2009·The Journal of Biological Chemistry·Paolo AscenziMauro Fasano
Mar 31, 2007·Skin Pharmacology and Physiology·N OtbergJ Lademann
Apr 26, 2008·The AAPS Journal·Munish AhujaDipak K Majumdar
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Christopher Grainge, Paul Rice
Mar 30, 2010·Biophysical Chemistry·Paolo Ascenzi, Mauro Fasano
May 19, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Radu M Nanau, Manuela G Neuman
Sep 16, 2003·Journal of Clinical Pharmacology·Pramod Kumar SharmaAnil Narang
Nov 28, 2012·International Journal of Clinical Practice. Supplement·D R Mehlisch, J Sykes
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marc LindenbergJennifer B Dressman
Mar 4, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Seigo SanohShigeru Ohta
Oct 19, 2016·Journal of Pharmaceutical Sciences·Rodrigo Cristofoletti, Jennifer B Dressman
Mar 3, 2001·Journal of Occupational and Environmental Medicine·J Borak, W F Diller
Oct 13, 2017·Drug Development and Industrial Pharmacy·Jake IrvineNazrul Islam
Nov 17, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Takafumi AkabaneToshio Teramura
Sep 1, 2019·Paediatric Anaesthesia·Brian J Anderson, Jacqueline A Hannam
Sep 29, 2020·Journal of Medicinal Chemistry·David A TessManthena V S Varma
Jun 9, 2006·Journal of Medicinal Chemistry·Johanna LinnankoskiMarjo Yliperttula

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