Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans.

European Journal of Nutrition
Carolina Alemán-JiménezAngel Gil-Izquierdo

Abstract

Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption and biovailability of dietary hydroxytyrosol and the influence of the dietary food-containing hydroxytyrosol on it. A double-blind study was performed including 20 volunteers who ingested 5 mg of hydroxytyrosol through diverse food matrices, to discover the influence on pharmacokinetics and bioavailability of HT metabolites (hydroxytyrosol acetate, 3,4-dihydroxyphenylacetic acid (DOPAC), tyrosol, and homovanillic alcohol) of the distinct matrices by UHPLC-ESI-QqQ-MS/MS. The HT pharmacokinetics after consumption of different food matrices was strongly dependent on the food matrix. In this aspect, the intake of extra virgin olive exhibited significantly higher plasma concentrations after 30 min of oral intake (3.79 ng/mL) relative to the control. Regarding the hydroxytyrosol bioavailability, the intake of extra virgin olive oil, as well as fortified refined olive, flax, and grapeseed oils provided significantly higher urinary...Continue Reading

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Citations

Mar 7, 2021·Nutrients·Annalisa NoceNicola Di Daniele
Apr 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Anjana PathaniaRajat Sandhir
Apr 29, 2021·Journal of Agricultural and Food Chemistry·Sebastià GalmésAndreu Palou
Jun 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Antonella Maria ArestaCarlo Zambonin

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