Abstract
The pharmacokinetics of zidovudine (ZDV) are established in patients with various stages of human immunodeficiency virus (HIV) disease. This study was conducted to determine the pharmacokinetic parameters of ZDV in patients with asymptomatic HIV infection and liver disease. HIV-infected volunteers with normal renal function were stratified according to the severity of liver disease (seven of eight were classified as mild). Each subject received a single intravenous dose of ZDV (120 mg) on the first day, followed by a single oral dose of ZDV (200 mg) on the second day. Blood samples were obtained over a 8-h collection interval, and concentrations of ZDV and its glucuronidated metabolite (GZDV) were determined by high-performance liquid chromatography. The following pharmacokinetic parameters were obtained after oral administration of ZDV to HIV-infected patients with mild hepatic disease; these values were compared with previously reported data in healthy volunteers. The area under the curve (AUC) (1,670 +/- 192 ng.h/ml), maximum concentration of drug in serum (1,751 +/- 180 ng/ml), and half-life (2.04 +/- 0.38 h) of ZDV were increased, while the apparent oral clearance (1.57 +/- 0.31 liter/h/kg of body weight) was decreased; AU...Continue Reading
References
Apr 1, 1976·Annals of Internal Medicine·H J ShullS Schenker
Mar 11, 1992·The Journal of Infectious Diseases·J A HavlikS E Thompson
Apr 1, 1992·The American Journal of Medicine·M Bonacini
Jul 15, 1991·Biochemical Pharmacology·A ResetarT Spector
Feb 1, 1991·The Journal of Infectious Diseases·D H WattsL Corey
Feb 1, 1991·British Journal of Clinical Pharmacology·E MagueurA M Taburet
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·G D MorseR C Reichman
Mar 1, 1990·AIDS·J D UnadkatL Corey
Jun 1, 1990·Clinical Pharmacology and Therapeutics·A M TaburetE Singlas
Jan 1, 1989·Drug Metabolism Reviews·T R TephlyM D Green
Nov 1, 1989·Clinical Pharmacology and Therapeutics·P de MirandaS Broder
Jul 1, 1989·Clinical Pharmacokinetics·J M Collins, J D Unadkat
Mar 1, 1989·Antiviral Research·G D MorseR C Reichman
Jan 1, 1989·European Journal of Clinical Pharmacology·B CrottyF J Dudley
Jan 1, 1989·European Journal of Clinical Pharmacology·E SinglasJ P Fillastre
Nov 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T TephlyY Irshaid
Sep 23, 1988·Journal of Chromatography·S S GoodP de Miranda
Jul 23, 1987·The New England Journal of Medicine·M A FischlR T Schooley
Jul 23, 1987·The New England Journal of Medicine·D D RichmanM S Hirsch
Apr 1, 1987·Clinical Pharmacology and Therapeutics·R W KleckerC E Myers
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Oct 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·S Riegelman, P Collier
Jul 29, 1993·The New England Journal of Medicine·D A CooperJ González-Lahoz
Citations
Jul 1, 1994·Journal of Clinical Pharmacology·S R BareggiA Lazzarin
Dec 3, 2013·Archives of Toxicology·Jia-Long FangJames C Fuscoe
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L DorneA G Renwick
Sep 19, 1997·Trends in Microbiology·M E KlepserM A Pfaller
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Wyles, John G Gerber
Nov 12, 1998·The Journal of Pharmacy and Pharmacology·K ParangE E Knaus
Jun 12, 2013·Journal of Pharmaceutical Sciences·Kelen C C SoaresJennifer Dressman
Jan 30, 2016·The AAPS Journal·Tom T G NieskensRosalinde Masereeuw
Jun 18, 2010·Enfermedades infecciosas y microbiología clínica·UNKNOWN Panel de Expertos de Gesida, UNKNOWN Plan Nacional sobre el Sida
Jun 25, 2009·Antiviral Research·Mario Alfredo Quevedo, Margarita Cristina Briñón
Oct 27, 2007·Journal of Clinical Pharmacology·Themba T NdoviCraig W Hendrix
Jun 21, 2016·Journal of Pharmaceutical Sciences·Teruo Murakami
Apr 13, 2005·Nucleosides, Nucleotides & Nucleic Acids·Evelyne MigianuMarc Lecouvey
Dec 16, 2004·Nucleosides, Nucleotides & Nucleic Acids·Y W WuY F Zhao
Aug 5, 2017·Acta Pharmacologica Sinica·Fan WangLi Liu
Feb 2, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tsuneo DeguchiTakashi Izumi
Nov 7, 2019·Biopharmaceutics & Drug Disposition·Liuya WeiDong-Hua Yang
Jun 12, 2017·Primate Biology·Matthias MietschChristiane Stahl-Hennig
Aug 5, 2020·Investigative Ophthalmology & Visual Science·Siddharth NarendranJayakrishna Ambati
Jun 1, 1997·Journal of Virology·J G JuliasV K Pathak
Jun 14, 2021·The Journal of Antimicrobial Chemotherapy·Yanmin Hu, Anthony Coates