Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation

The Journal of Antimicrobial Chemotherapy
Pavel GershkovichKishor M Wasan

Abstract

To assess the pharmacokinetics and biodistribution of amphotericin B (AmB) following oral administration in a novel mono/diglyceride-phospholipid formulation and to compare with intravenous (iv) administrations using commercial formulations. Rats were allocated into the following treatment groups: oral gavage of AmB dispersed in mono/diglyceride-phospholipid formulation at doses of 4.5 and 10 mg/kg; iv bolus administration of 0.8 mg/kg Fungizone; iv bolus of 5 mg/kg Abelcet and iv bolus of 5 mg/kg AmBisome. Blood was sampled from jugular vein cannula at certain time points. The animals were sacrificed 72 h following administration of AmB and multiple tissues were harvested. The concentration of AmB in plasma and tissues was determined by means of HPLC. The plasma creatinine concentrations were determined using an enzymatic kit. The pharmacokinetics and tissue distribution of AmB following iv administrations of the commercial formulations were found to be highly formulation dependent. The terminal half-life and biodistribution of orally administered AmB in a mono/diglyceride-phospholipid formulation resembled those of Fungizone. The larger volume of the co-administered lipid-based formulation in the case of the higher dose of or...Continue Reading

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Citations

Dec 23, 2009·The Journal of Antimicrobial Chemotherapy·Pavel GershkovichKishor M Wasan
Feb 14, 2013·Therapeutic Delivery·Juan J TorradoIjeoma F Uchegbu
Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
Jul 28, 2013·Expert Opinion on Drug Delivery·Moayad AlhaririAbdelwahab Omri
Jun 26, 2014·Drug Development and Industrial Pharmacy·Jo-Ann Osei-Twum, Kishor M Wasan
Apr 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·M AlsaadiK C Carter
Mar 1, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fady IbrahimKishor M Wasan
Mar 9, 2010·Trends in Microbiology·David W Denning, William W Hope
Jun 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Subhashis ChakrabortySanjay Singh
Jul 19, 2016·Parasitology International·Mariana Costa DuarteEduardo Antonio Ferraz Coelho
Jul 2, 2016·Parasitology Research·Letícia Martins Dos Reis LageMariana Costa Duarte
Jun 25, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Miguel Angel Chávez-FumagalliEduardo Antonio Ferraz Coelho
Jul 5, 2017·Drug Development and Industrial Pharmacy·Ronak SavlaEllen K Wasan
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Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chaolong QinPavel Gershkovich
Oct 6, 2018·Carbohydrate Polymers·Rossana Gabriela Del Jesus Vásquez MarcanoRubiana Mara Mainardes

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