PMID: 8583542Aug 1, 1995Paper

Pharmacokinetics and bioequivalence of parenterally administered doramectin in cattle

Journal of Veterinary Pharmacology and Therapeutics
M A NowakowskiR M Jones

Abstract

Plasma concentrations of doramectin in 40 cattle dosed by subcutaneous (sc) or intramuscular (i.m.) injection (200 micrograms/kg) were compared to assess the bioequivalence of the two routes of administration. Peak concentration (Cmax), and areas under the concentration curve (AUC0-infinity) were determined from plasma concentrations. Animals treated by the sc route showed a mean AUC0-infinity of 457 +/- 66 ng.day/mL (+/- SD) and a mean Cmax of 27.8 +/- 7.9 ng/mL. Results from the i.m. treatment group showed a mean AUC0-infinity of 475 +/- 82 ng.day/mL and a mean Cmax of 33.1 +/- 9.0 ng/mL. Absorption constants (ka) determined by modelling were 0.542 +/- 0.336 day-1 after sc administration and 0.710 +/- 0.357 day-1 after i.m. administration. The 90% confidence limits on the difference between mean AUC0-infinity values for the sc and i.m. groups fell within 20% of the mean value for the subcutaneous group. Cmax was somewhat greater for the i.m. route. The 90% confidence limits on the difference in mean In(Tmax +1) also fell within 20% of the mean sc value. Based on this analysis, bioequivalence of the sc and i.m. formulation has been established.

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Citations

Jan 17, 2008·Parasitology Research·Rubén PérezIgnacio Cabezas
Mar 29, 2003·Toxicology and Applied Pharmacology·Pamela L ChamberlainJurgen von Bredow
Dec 24, 1997·Veterinary Parasitology·P L ToutainM E McKenzie
Dec 24, 1997·Veterinary Parasitology·S RanjanR S Rew
Dec 24, 1997·Veterinary Parasitology·G E Moya-BorjaM E McKenzie
Mar 20, 2003·Journal of Pharmaceutical and Biomedical Analysis·J G PrietoA I Alvarez
Apr 16, 1998·Journal of Pharmaceutical and Biomedical Analysis·A C Harrison, D K Walker
Apr 4, 2000·Journal of Veterinary Pharmacology and Therapeutics·A H Atta, M N Abo-Shihada
Oct 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·Q A McKellar, H A Benchaoui
Sep 30, 1999·Research in Veterinary Science·E EscuderoM Alvinerie
Jul 25, 2008·Veterinary Parasitology·K P HemaprasanthM R Raghunath
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·R P HunterM A Goatley
Jan 8, 2008·Journal of Veterinary Pharmacology and Therapeutics·R PérezM Arboix
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·R PérezJ Cox
Oct 29, 2005·The Veterinary Journal·Rubén PérezMargarita Arboix
Jan 18, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·R PérezM Alvinerie
Jul 31, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·R PérezM Alvinerie
Sep 5, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin DanaherMichael O'Keeffe
May 2, 2003·Journal of Agricultural and Food Chemistry·Fernanda A ImperialeCarlos E Lanusse

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