Pharmacokinetics and brain penetration study of chlorogenic acid in rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Gaurav KumarRanjana Patnaik

Abstract

1. The present study is designed to investigate the brain distribution and plasma pharmacokinetics profiles of chlorogenic acid (CGA) after intranasal administration in Charles-Foster rats to evaluate whether the CGA molecules are transported directly via the nose-to-brain path. 2. The CGA is administered intravenously (IV) and intranasally (IN) at the dose of 10 mg/kg. Further, its concentration in the plasma, cerebrospinal fluid (CSF) and the whole brain is analyzed by HPLC-UV method. 3. The study observes that CGA is rapidly absorbed in plasma with tmax of 1 min similar to IV route after IN administration. The peak plasma concentration and AUC0-24 are higher by 3.5 and 4.0 times respectively in IV administration, compared to IN delivery that represents the significant less systemic exposure of CGA in IN route. 4. However, the concentration of CGA in the brain is 4, 6.5, 5.3, 5.2 and 4.5 times higher at 30, 60, 120, 240 and 360 min, respectively in IN administration compared to IV administration. The exposure of CGA in the brain after IN administration (AUCbrain, IN) was significantly greater (4 times) as compared to the exposure of CGA in the brain (AUCbrain, IV) after IV administration reflecting significant brain uptake of...Continue Reading

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Citations

Apr 1, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Pankaj PaliwalSairam Krishnamurthy
Dec 31, 2019·Journal of Food and Drug Analysis·Chien-Min LinMei-Hsien Lee
Jun 14, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Gaurav KumarRanjana Patnaik
Aug 22, 2018·Frontiers in Pharmacology·Saumitra S SinghSurya P Singh
Sep 24, 2021·Journal of Agricultural and Food Chemistry·Hui XuMingfu Wang

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