PMID: 2501512Jun 1, 1989Paper

Pharmacokinetics and cardio-respiratory effects of oral theophylline in exercised horses

Journal of Veterinary Pharmacology and Therapeutics
C Ingvast-LarssonB Wiese

Abstract

The pharmacokinetics of theophylline at rest and the effects on cardio-respiratory and blood lactate responses to exercise were investigated after repeated oral administrations in six healthy Standardbred horses. A dose of 5 mg/kg body weight was administered every 12 h. The binding of theophylline to plasma protein was also determined. There was good agreement between predicted and observed plasma concentrations of theophylline at steady state. The mean half-life of elimination was shown to be 17.0 +/- 2.5 h, the mean half life of absorption was 1.6 +/- 1.8 h, the apparent volume of distribution was 852 +/- 99.0 ml/kg and total plasma clearance 0.61 +/- 0.08 ml/kg/min. Theophylline showed very low plasma protein binding (12%). The heart rate and blood lactate levels, during and after exercise, were significantly increased during theophylline-treatment. There was an increase of the arterial oxygen tension after exercise and the arterial carbon dioxide values before and after exercise were significantly lower than the premedication values. No severe adverse effects of the drug were noted. The recommended oral dose is therefore 5 mg/kg every 12 h but due to inter-individual variation, an adjustment of the dose may be necessary. T...Continue Reading

References

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Citations

Sep 28, 1999·Journal of Veterinary Pharmacology and Therapeutics·I A WasfiS A Wajid
Sep 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·C Ingvast-Larsson
Dec 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·C Ingvast-LarssonG Nyman

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