PMID: 9430767Feb 7, 1998Paper

Pharmacokinetics and cardiopulmonary effects of guaifenesin in donkeys

Journal of Veterinary Pharmacology and Therapeutics
N S MatthewsA C Ray

Abstract

Five donkeys and three horses were given guaifenesin, intravenously, by gravity administration, until recumbency was produced. The time and dose required to produce recumbency, recovery time to sternal and standing were recorded. Blood samples were collected for guaifenesin assay at 10, 20, 30, 40, 50, 60 min, and 2, 3, 4 and 6 h after guaifenesin administration. Serum was analysed for guaifenesin using HPLC and pharmacokinetic values were calculated using a computer software package (RSTRIP). In donkeys, heart and respiratory rates and blood pressures were recorded before and at 5-min intervals during recumbency. Arterial blood samples were collected before and at 5 and 15 min intervals during recumbency for analysis of pH, CO2, and O2. ANOVA was used to evaluate dynamic data, while t-tests were used for kinetic values. Respiratory rate was decreased significantly during recumbency, but no other significant changes from baseline occurred. The mean (+/- SD) recumbency dose of guaifenesin was 131 mg/kg (27) for donkeys and 211 mg/kg (8) for horses. Recovery time to sternal (min) was 15 (SD, 11) for donkeys and 34 (SD, 1.4) for horses. Time to standing was 32 min for donkeys and 36 min for horses. Calculation of AUC (area under t...Continue Reading

Citations

Sep 8, 2010·Rejuvenation Research·Mark E ObrenovichV Prakash Reddy
Mar 26, 2002·American Journal of Veterinary Research·Kenneth E PeckKatrina L Mealey
Dec 1, 2011·American Journal of Veterinary Research·Robert J BrosnanOliver Fiehn
Jan 15, 2016·Journal of Veterinary Pharmacology and Therapeutics·H K KnychR M Arthur
Dec 12, 2013·Journal of Veterinary Pharmacology and Therapeutics·M J RumplerR A Sams
Oct 1, 2013·The Veterinary Record·J M Senior
Oct 13, 2017·Acta Veterinaria Scandinavica·Cecilia VulloGiuseppe Catone
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Paola StraticòLucio Petrizzi
Jun 26, 2014·Veterinary Anaesthesia and Analgesia·Cássia M Molinaro CoelhoLuiz Antonio F da Silva

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