Pharmacokinetics and clearance of ganciclovir during continuous hemodiafiltration

Critical Care Medicine
Satoshi GandoY Nakanishi

Abstract

To evaluate the ganciclovir pharmacokinetics and clearance during continuous venovenous hemodiafiltration. Case report. General intensive care unit of a tertiary care emergency department. A 63-yr-old female who has a history of active behçet's disease that has been controlled with oral prednisolone, and who has chronic renal failure. None. A 5-mg/kg dosage of ganciclovir was administered intravenously over a 60-min period under continuous venovenous hemodiafiltration. Samples from the arterial and venous blood catheters and from the ultradiafiltrate were collected over the next 12 hrs to calculate pharmacokinetic parameters and clearance of hemodiafiltration. The pharmacokinetic parameters were as follows: half-life of elimination phase 12.6 hrs; total clearance 0.55 mL/min/kg; and volume distribution of steady state 27.07 L. The clearance of hemodiafiltration was 0.63 mL/min/kg. Continuous venovenous hemodiafiltration is effective in removing ganciclovir from the blood.

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Citations

Apr 3, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumi SuzukiHiroyasu Ogata
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Thomas HorvatitsPeter Schenk
Nov 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Chris StockmannCatherine Mt Sherwin
Apr 17, 2009·Néphrologie & thérapeutique·Vincent BourquinPierre-Yves Martin
May 8, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew S JarrellMark A Marzinke

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