PMID: 9179722May 1, 1997Paper

Pharmacokinetics and disposition of methyl t-butyl ether in Fischer-344 rats

Journal of Applied Toxicology : JAT
M J MillerJ J Kneiss

Abstract

Methyl t-butyl ether (MTBE) is a commonly used octane booster in gasoline. This study examines the pharmacokinetics and disposition of MTBE in Fischer-344 rats after i.v., oral, dermal and inhalation routes of administration. Groups of male and female rats were given single i.v. (40 mg kg-1), oral (40 and 400 mg kg-1) and dermal (40 and 400 mg kg-1 in occluded chambers) doses of [14C]MTBE. For inhalation studies, rats were exposed nose-only for 6 h to low (400 ppm), high (8000 ppm) and repeated daily 6-h low (400 ppm x 15 days) chamber concentrations of [14C]MTBE. Blood, expired air, and excreta (urine and feces) were collected at selected times up to 7 days post-dose and quantified for 14C content. Plasma concentrations of MTBE and t-butyl alcohol (TBA) were quantified and mean values used for pharmacokinetic analysis. The mean total recoveries of 14C ranged from 91 to 105%. Methyl t-butyl ether was rapidly and completely absorbed after oral and inhalation exposures; dermal absorption was low. After all routes, MTBE was rapidly eliminated from blood (ti = 0.5 h) by exhalation and metabolism to TBA. At the high doses, metabolism was saturated and the proportion of renal 14C excretion decreased relative to the pulmonary route. A...Continue Reading

Citations

Oct 31, 2001·Toxicology Letters·W DekantA Amberg
Dec 19, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Arastoo SaeediAfshin Mohammadi-Bardbori
Sep 29, 2015·Critical Reviews in Toxicology·Kenneth T Bogen, Jacqueline M Heilman
May 18, 1999·Toxicology and Applied Pharmacology·J S Prescott-MathewsS J Borghoff
Jun 24, 2014·Regulatory Toxicology and Pharmacology : RTP·Derek SwickHerb Estreicher
May 31, 2003·Journal of Toxicology and Environmental Health. Part a·Janet M BensonEdward B Barr
Mar 10, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Teresa L Leavens, Susan J Borghoff
Nov 25, 2003·Journal of Applied Toxicology : JAT·Susan C J SumnerTimothy R Fennell
Jul 1, 2006·Critical Reviews in Toxicology·Douglas McGregor

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