PMID: 3213936Oct 1, 1988Paper

Pharmacokinetics and dynamics of endogenously released and therapeutically administered adrenaline in resuscitation. A comparative animal experimental study

Der Anaesthesist
U HörnchenW Eichelkraut

Abstract

In this study, catecholamine plasma levels and hemodynamic response were measured to compare the effects of endogenously released (group A; n = 8), intravenously injected (group B; 10 micrograms/kg; n = 8), and endobronchially instilled (e.b.) epinephrine (group C; 100 micrograms/kg; n = 8) on resuscitation. Although the endogenous release of epinephrine produced peak plasma concentrations of 214 +/- 86 ng/ml (mean +/- SEM) during cardiac massage, only 5 animals were successfully resuscitated in group A. Mean arterial pressure and cardiac output were significantly lower in the first hour of restored spontaneous circulation compared to groups B and C. Endobronchial and intravenous epinephrine administration proved equally effective with regard to resuscitability and hemodynamic response during cardiac massage. All animals in groups B and C were successfully resuscitated and peak plasma concentrations of epinephrine were achieved with comparable onset times (317 +/- 53 ng/ml after 2.5 min in group B, 634 +/- 202 ng/ml after 3 min in group C). The tenfold epinephrine dose administered endobronchially was able to generate only a twofold increase in peak plasma epinephrine concentrations. The mean bioavailability with this route of ...Continue Reading

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