Pharmacokinetics and haematological parameters of recombinant human erythropoietin after subcutaneous administrations in horses

Biopharmaceutics & Drug Disposition
A SouillardR Gareau

Abstract

The pharmacokinetics of recombinant human Epo (rHuEpo) were investigated after subcutaneous administration to horses. Four horses received a single 30IU kg-1 dose of rHuEpo. One horse received three repeated doses of 120 IU kg-1 at 48 h intervals. Plasma erythropoietin (Epo) was measured by radioimmunoassay. In both cases pharmacokinetic parameters were evaluated using a one-compartment open model and first-order input and output rates. The mean values (+/-SD) for elimination half-life, CL/F, and Vd/F after a single dose were 12.9 +/- 3.34 h, 11.8 +/- 4.96 L h-1, and 233 +/- 126 L, respectively. After repeated doses, elimination half-life, CL/F, and Vdss/F were 11.3 h, 8.94 L h-1, and 145.6 L, respectively. No significant differences were observed between the haematological parameters after a single 30 IU kg-1 administration compared to baseline values. Multiple and high doses of rHuEpo modified red blood cells, haemoglobin, and hematocrit. According to our results, plasma Epo assay can help, during an antidoping control procedure, to support a positive result only up to 72 h after the last rHuEpo.

Citations

Apr 4, 2007·Equine Veterinary Journal. Supplement·K H McKeeverG A Maylin
Jun 12, 2009·Electrophoresis·Max GassmannJohannes Vogel
Aug 6, 2010·Drug Testing and Analysis·Ludovic Bailly-ChouriberryYves Bonnaire
Apr 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Rohini RamakrishnanWilliam J Jusko
Mar 30, 2017·Drug Testing and Analysis·Tessa WilkinNatasha Hamilton
Aug 17, 2005·Journal of Applied Physiology·C CooperD Bienzle

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