Pharmacokinetics and inflammatory fluid penetration of clinafloxacin.

Antimicrobial Agents and Chemotherapy
R WiseJ M Andrews

Abstract

A single 200-mg dose of clinafloxacin was given orally to each of nine healthy male volunteers, and the concentrations of the drug were measured in plasma, cantharidin-induced inflammatory fluid, and urine over the following 24 h (48 h in the case of urine). The mean maximum concentration in plasma was 1.34 microg/ml at a mean time of 1.8 h postdose. The mean maximum concentration in the inflammatory fluid was 1.3 microg/ml at 3.8 h postdose. The mean elimination half-life of clinafloxacin in plasma was 5.65 h. The overall penetration into the inflammatory fluid was 93.1%, as assessed by determining the ratio of area under the concentration-time curves. Recovery of clinafloxacin in urine was 58.8% by 24 h and 71.8% by 48 h postdose.

References

Nov 1, 1992·Antimicrobial Agents and Chemotherapy·J H JohnsonR Wise
Aug 1, 1988·Antimicrobial Agents and Chemotherapy·R WiseJ M Andrews
Aug 1, 1988·Antimicrobial Agents and Chemotherapy·S R Norrby, M Jonsson
Oct 1, 1988·Antimicrobial Agents and Chemotherapy·J W StoneR Wise
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Jul 1, 1980·The Journal of Infectious Diseases·R WiseS Baker
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·R WiseJ M Andrews
Dec 1, 1996·The Journal of Antimicrobial Chemotherapy·N J BronA B Vassos

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Citations

Feb 13, 2001·Antimicrobial Agents and Chemotherapy·G SiamiUNKNOWN Severe Skin and Soft Tissue Infections Study Group
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·E J RandinitisA B Vassos
Dec 13, 2006·Treatments in Respiratory Medicine·George G ZhanelDaryl J Hoban

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