Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: thigh versus abdomen

Clinical Endocrinology
T LaursenJ S Christiansen

Abstract

The absorption of insulin following subcutaneous (s.c.) injection is faster in the abdomen than the thigh. We therefore studied the effect of changing the site of injection on the absorption and metabolic effects of human growth hormone. In a cross-over study human GH (Norditropin) was injected s.c. in the thigh or abdomen in random order. Ultrasonography of the thigh and abdomen was performed in order to evaluate the thickness of the s.c. tissue. After each treatment period (4 weeks), serum profiles of GH, IGF-I, IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3), glucose, insulin, non-esterified fatty acids (NEFA), glycerol, 3-hydroxybutyrate, alanine, lactate and glucagon were measured for 37 hours after GH injection (3 IU/m2 at 1900 hour). Nine GH deficient patients (five males, four females). The mean (+/- SEM) thickness of the s.c. tissue (mm) was higher on the abdominal site (9.35 +/- 1.38 (thigh), and 22.61 +/- 2.19 (abdomen), P < 0.001). Mean (+/- SEM) integrated levels (area under the curves (AUC) divided by time) of GH (mU/l) were identical: 5.54 +/- 0.70 (thigh) versus 5.48 +/- 0.64 (abdomen) (P = 0.91). AUC (mU/l) for the initial 6 hours were, however, significantly different (14.10 +/- 3.76 (thigh) and 19.02 +/- 3...Continue Reading

References

Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·D K Snyder, D R Clemmons
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S D Frasier, B M Lippe
Jul 5, 1990·The New England Journal of Medicine·D RudmanD E Mattson
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
May 1, 1988·The American Journal of Clinical Nutrition·M Abu KhaledR L Weinsier
Mar 1, 1984·Diabetes Care·C BinderS Pramming
Apr 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·A AstrupJ Madsen

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Citations

Apr 15, 2005·Clinical Pharmacokinetics·Iftekhar Mahmood, Martin D Green
Nov 27, 2009·Journal of Clinical Pharmacology·Zhenhua XuHonghui Zhou
May 8, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerLars Rejnmark
Jul 28, 2009·Cancer Chemotherapy and Pharmacology·Susan F HudachekDaniel L Gustafson
Aug 8, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wolfgang F Richter, Björn Jacobsen
Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Torben Laursen

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