Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Hirotaka AmanoKenji Itoh

Abstract

1. Pharmacokinetics and N-acetylation metabolism of S-methyl-L-cysteine (SMC) and trans-S-1-propenyl-L-cysteine (S1PC) were examined in rats and dogs. SMC and S1PC (2-5 mg/kg) were well absorbed in both species with high bioavailability (88-100%). 2. SMC and S1PC were excreted only to a small extent in the urine of rats and dogs. The small renal clearance values (<0.03 l/h/kg) indicated the extensive renal reabsorption of SMC and S1PC, which potentially contributed to their long elimination half-lives (>5 h) in dogs. 3. S1PC, but not SMC, underwent N-acetylation extensively in vivo, which can be explained by the relative activities of N-acetylation of S1PC/SMC and deacetylation of their N-acetylated forms, N-acetyl-S1PC/N-acetyl-SMC, in the liver and kidney in vitro. The activities for S1PC N-acetylation were similar to or higher than those for N-acetyl-S1PC deacetylation in liver S9 fractions of rat and dog, whereas liver and kidney S9 fractions of rat and dog had little activity for SMC N-acetylation or considerably higher activities for N-acetyl-SMC deacetylation. 4. Our study demonstrated that the pharmacokinetics of SMC and S1PC in rats and dogs was characterized by high bioavailability and extensive renal reabsorption; ho...Continue Reading

References

Mar 1, 1968·The Biochemical Journal·N M Sklan, E A Barnsley
Oct 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S C MitchellG F Aldington
Apr 1, 1994·Journal of Toxicology and Environmental Health·C A Hinchman, N Ballatori
Jul 1, 1993·Pharmaceutical Research·B Davies, T Morris
Mar 10, 2001·The Journal of Nutrition·H AmagaseY Itakura
Dec 1, 2004·The Journal of Nutrition·Cheng-Chin HsuChang-Hung Hsieh
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Cristino CruzJosé Pedraza-Chaverri
Sep 4, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shin Chet ChuahYi Zhun Zhu
Nov 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramez WassefToshinori Hoshi
Jan 28, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Meri P NantzSusan S Percival
Feb 15, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hirotaka AmanoYukihiro Kodera

❮ Previous
Next ❯

Citations

Apr 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yukihioro KoderaToshiaki Matsutomo
Feb 6, 2020·Experimental and Therapeutic Medicine·Jun-Ichiro SuzukiYukihiro Kodera
Jul 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tharsini SivapalanShikha Saha
Sep 22, 2018·Scientific Reports·Jun-Ichiro SuzukiNaoaki Morihara
Dec 11, 2020·Seminars in Cancer Biology·Danielle De GreefAnupam Bishayee
Mar 3, 2018·Journal of Agricultural and Food Chemistry·Masashi NakamotoYukihiro Kodera
Aug 23, 2021·Molecular and Cellular Biochemistry·Salim M A BastakiE Adeghate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Hirotaka AmanoYukihiro Kodera
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
D A SmithD K Walker
Journal of Pharmaceutical Sciences
J E SwagzdisB A Mico
© 2022 Meta ULC. All rights reserved