Pharmacokinetics and pharmacodynamics of cefepime in patients with various degrees of renal function.

Antimicrobial Agents and Chemotherapy
Vincent H TamMichael J Rybak

Abstract

This study evaluated the pharmacokinetics of cefepime in 36 patients with different levels of renal function. Pharmacokinetic and pharmacodynamic parameters were calculated using samples obtained at steady state. Patients with creatinine clearance (CL(CR)) of >100 ml/min had more rapid clearance (CL) and a lower minimum concentration in serum (C(min)). C(min) in this group was found to be 3.3 +/- 3.6 mg/liter (mean and standard deviation), compared to 19.5 +/- 21.5 mg/liter in patients with a CL(CR) of between 60 and 100 ml/min (P = 0.025) and 14.0 +/- 11.5 mg/liter in patients with a CL(CR) of <60 ml/min (P = 0.009). Patient data were also analyzed by the nonparametric expectation maximization method and Bayesian forecasting. The median volume of distribution in the central compartment was 27.08 liters. CL and CL(CR) were highly correlated (P = 0.00033) according to the equation CL= 0.324 liters/h + (0.0551 x CL(CR)). The median rate constants from the central compartment to the peripheral compartment and from the peripheral compartment to the central compartment were 12.58 and 41.09 h(-1), respectively. The time-concentration profiles for 1,000 patients (CL(CR)s, 120, 60, and 30 ml/min) each receiving various dosing regimens ...Continue Reading

Associated Clinical Trials

Feb 11, 2016·Stijn Jonckheere

References

Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1992·Antimicrobial Agents and Chemotherapy·R H BarbhaiyaK A Pittman
Mar 1, 1992·Antimicrobial Agents and Chemotherapy·R H BarbhaiyaR R Martin
Jun 1, 1990·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·S C Ebert, W A Craig
Sep 1, 1990·Clinical Pharmacology and Therapeutics·R H BarbhaiyaK A Pittman
Oct 1, 1988·The Journal of Infectious Diseases·B VogelmanW A Craig
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·R E KesslerF Leitner
May 1, 1985·Antimicrobial Agents and Chemotherapy·P C FuchsC Thornsberry
Dec 1, 1995·Pharmaceutical Research·E I Ette, T M Ludden
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·C R BonapaceJ A Bosso
Jun 14, 2000·Neurology·S DixitR D Sheth
Sep 3, 2002·The Journal of Antimicrobial Chemotherapy·Vincent H TamGeorge L Drusano

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Citations

Feb 3, 2012·The Journal of Antimicrobial Chemotherapy·Charlotte Durand-MaugardMichel Andréjak
Dec 30, 2009·Antimicrobial Agents and Chemotherapy·Jared L CrandonDavid P Nicolau
May 29, 2008·Antimicrobial Agents and Chemotherapy·Tze-Peng LimVincent H Tam
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Edmund CapparelliFernando Moya
Jul 17, 2007·Clinical Microbiology Reviews·John Turnidge, David L Paterson
Jun 9, 2011·Critical Care : the Official Journal of the Critical Care Forum·Lucie SeylerFrédérique Jacobs
Apr 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Thomas M ChapuisPhilippe Moreillon
Dec 17, 2009·Clinical Pharmacokinetics·Andrew A UdyJeffrey Lipman
Jan 30, 2014·The Journal of Antimicrobial Chemotherapy·Marcelle D AlvesAlexandre P Zavascki
Dec 5, 2008·Expert Review of Anti-infective Therapy·Andrea EndimianiRobert A Bonomo
Jun 16, 2005·Expert Review of Anti-infective Therapy·Edgar L Schuck, Hartmut Derendorf
Jul 11, 2008·Expert Opinion on Drug Safety·Lorenzo Drago, Elena De Vecchi
Mar 24, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine K PerezJames S Lewis
Nov 16, 2010·International Journal of Antimicrobial Agents·S Christian CheathamMichael B Kays
Mar 14, 2007·Diagnostic Microbiology and Infectious Disease·C Andrew DeRykeDavid P Nicolau
Feb 10, 2006·Pharmacotherapy·Scott T MicekMarin H Kollef
Jul 4, 2006·Advances in Chronic Kidney Disease·Amy Barton Pai, Manjunath P Pai
Jun 13, 2006·Diagnostic Microbiology and Infectious Disease·Thomas D NolinRobert C Owens
Jun 5, 2004·Clinics in Laboratory Medicine·Fernanda SilveiraDavid L Paterson
Mar 10, 2005·The Medical Clinics of North America·Steven Gabardi, Stuart Abramson
Mar 30, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pornpan KoomanachaiDavid P Nicolau
Mar 8, 2014·Diagnostic Microbiology and Infectious Disease·Stijn BlotJason A Roberts
Jun 2, 2016·The Journal of Antimicrobial Chemotherapy·Stijn JonckheerePieter Colin
Aug 17, 2004·Infectious Disease Clinics of North America·Margaret Trexler Hessen, Donald Kaye
Jul 6, 2011·International Journal of Antimicrobial Agents·Sutep JaruratanasirikulWibul Wongpoowarak

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