Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children

The Journal of Clinical Endocrinology and Metabolism
C PihokerC Y Bowers

Abstract

Administration of GH-releasing peptide-2 (GHRP-2) represents a potential mode of therapy for children of short stature with inadequate secretion of GH. Requisite information to determine the dosing route and frequency for GHRP-2 consists of the pharmacokinetics (PK) and pharmacodynamics (PD) for this compound, neither of which have been previously evaluated in children. The purpose of this study was to characterize the PK and PD of GHRP-2 in children with short stature. Ten prepubertal children (nine boys and one girl; 7.7 +/- 2.4 yr old) received a single 1 microg/kg i.v. dose of GHRP-2 over 1 min, followed by repeated (n = 9) blood sampling over 2 h. GHRP-2 and GH were quantitated by specific RIA methods. PK parameters were calculated from curve fitting of GHRP-2 and GH vs. time data. Posttreatment plasma GH concentrations (normalized for pretreatment values) were used as the effect measurement. PD parameters were generated using the sigmoid Emax model. Disposition of GHRP-2 best fit a biexponential function. GHRP-2 PK parameters (mean +/- SD) were: alpha = 13.4 +/- 9.7 h(-1), beta = 1.3 +/- 0.3 h(-1), t(1/2beta) = 0.55 +/- 0.14 h, AUC(0-infinity) = 2.02 +/- 1.37 ng/mL x h, Cmax = 7.4 +/- 3.8 ng/mL, plasma clearance = 0.66 +/...Continue Reading

Citations

Feb 9, 2005·The Journal of Clinical Endocrinology and Metabolism·Blandine LaferrèreCyril Y Bowers
Mar 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catalina NormanJohannes D Veldhuis
Jan 10, 2002·Journal of Pharmaceutical Sciences·Bernd Meibohm, Hartmut Derendorf
Oct 27, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ania CabralesLuis Javier González

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