PMID: 22580527May 15, 2012Paper

Pharmacokinetics and pharmacodynamics of propofol in patients undergoing abdominal aortic surgery

Pharmacological Reports : PR
Paweł WiczlingEdmund Grześkowiak

Abstract

Available propofol pharmacokinetic protocols for target-controlled infusion (TCI) were obtained from healthy individuals. However, the disposition as well as the response to a given drug may be altered in clinical conditions. The aim of the study was to examine population pharmacokinetics (PK) and pharmacodynamics (PD) of propofol during total intravenous anesthesia (propofol/fentanyl) monitored by bispectral index (BIS) in patients scheduled for abdominal aortic surgery. Population nonlinear mixed-effect modeling was done with Nonmem. Data were obtained from ten male patients. The TCI system (Diprifusor) was used to administer propofol. The BIS index served to monitor the depth of anesthesia. The propofol dosing was adjusted to keep BIS level between 40 and 60. A two-compartment model was used to describe propofol PK. The typical values of the central and peripheral volume of distribution, and the metabolic and inter-compartmental clearance were V(C) = 24.7 l, V(T) = 112 l, Cl = 2.64 l/min and Q = 0.989 l/min. Delay of the anesthetic effect, with respect to plasma concentrations, was described by the effect compartment with the rate constant for the distribution to the effector compartment equal to 0.240 min(-1). The BIS inde...Continue Reading

References

Jul 1, 1991·British Journal of Anaesthesia·B MarshG N Kenny
Nov 1, 1993·Journal of Clinical Anesthesia·S L Shafer
Jun 26, 1998·Anaesthesia·C F SwinhoeC S Reilly
Mar 12, 1999·British Journal of Clinical Pharmacology·J X Mazoit, K Samii
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Mar 17, 2000·Anesthesiology·J Schüttler, H Ihmsen
Jun 22, 2000·Biomedical Chromatography : BMC·A L DawidowiczA Fijalkowska
Nov 5, 2003·Biomedical Chromatography : BMC·Andrzej L Dawidowicz, Rafał Kalityński
Jun 9, 2004·Anesthesiology Clinics of North America·Timothy S J Shine, Michael J Murray
Jan 25, 2005·British Journal of Anaesthesia·F CavaliereR Proietti
Mar 9, 2005·Acta Anaesthesiologica Scandinavica·Y U AdachiK Watanabe
Aug 10, 2007·Clinical Pharmacology and Therapeutics·M Y M PeetersC A J Knibbe
Nov 13, 2007·European Journal of Clinical Pharmacology·Mariska Y M PeetersCatherijne A J Knibbe
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Hiroko TakahashiYoshihiro Takeuchi
May 16, 2009·Current Drug Metabolism·Juan G RestrepoJosé A G Agúndez
Jun 13, 2009·British Journal of Anaesthesia·A R AbsalomM M R F Struys
Aug 26, 2009·Current Drug Metabolism·Sui-Lin MoShu-Feng Zhou
Apr 24, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Marcus A BjörnssonUlrika S H Simonsson
Jun 15, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Agnieszka BienertMiłosz Regulski

❮ Previous
Next ❯

Citations

Aug 26, 2014·Pharmacological Reports : PR·Alicja Bartkowska-ŚniatkowskaEdmund Grześkowiak
Aug 21, 2015·CNS Drugs·Vidya ChidambaranAjay D'Mello
Jan 30, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Krzysztof PrzybyłowskiEdmund Grześkowiak
May 30, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Iman A El-BarakyNirmeen A Sabry
Aug 3, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dong DongBaojian Wu
Oct 28, 2016·Biopharmaceutics & Drug Disposition·Piotr SmuszkiewiczAgnieszka Bienert
Aug 26, 2020·Journal of Pharmacokinetics and Pharmacodynamics·Agnieszka BienertPaweł Wiczling
Nov 19, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jiang ZongmingFang Xiangming

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.