Jul 4, 2006

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

The Journal of Antimicrobial Chemotherapy
Kenneth N Agwuh, Alasdair MacGowan

Abstract

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.

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Mentioned in this Paper

Tetracycline Antibiotics
Tetracyclines
Doxycycline
Rolitetracycline
Oxytetracycline
Chlortetracycline
Minocycline
Pharmacodynamics
Glycylcycline
Tigecycline

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