PMID: 11907637Mar 22, 2002Paper

Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A

Journal of Cardiovascular Pharmacology and Therapeutics
J W ParkW Jaross

Abstract

During the last decades, transplantation has become an established tool for the treatment of terminal organ failure. Beside immunological factors, hyperlipidemia is the main problem after heart transplantation, causing rapid transplant coronary artery disease (TxCAD) and poor long-term prognosis at the beginning of the transplantation. Heart transplant recipients are now effectively treated with lipid lowering substances, of which HMG-CoA-reductase inhibitors are the most potent. However, treatment with these substances correlates with an increased risk for the development of rhabdomyolysis due to therapy with the immunosuppressive cyclosporine A. Our study monitored the safety and efficacy of treatment with the HMG-CoA reductase inhibitor fluvastatin in heart transplant recipients compared to healthy controls. We investigated 10 patients receiving immunosuppressive therapy consisting of cyclosporine A, prednisone, and azathioprine who had increased concentrations of LDL-cholesterol (LDL-C), and 10 age-matched healthy controls. The patients were treated with 40 mg/day fluvastatin for 4 weeks and 20 mg/day for 4 additional weeks. Control individuals received 40 mg/day fluvastatin for 4 weeks only. Parameters of fluvastatin pharm...Continue Reading

References

Jun 1, 1992·Journal of the American Society of Nephrology : JASN·J D PirschF O Belzer
May 11, 1992·Journal of the American College of Cardiology·C M BallantyneA M Gotto
Jul 7, 1989·JAMA : the Journal of the American Medical Association·C M BallantyneJ B Young
Oct 1, 1995·Clinical Pharmacology and Therapeutics·C TransonP Dayer
Feb 23, 1995·The New England Journal of Medicine·G N LevineJ A Vita
Feb 1, 1996·Clinical Pharmacokinetics·C CampanaM Molinaro
Nov 1, 1996·Clinical Pharmacokinetics·J P Desager, Y Horsmans
Feb 1, 1997·Transplantation Proceedings·H PodderJ Járay
Aug 5, 1998·British Journal of Clinical Pharmacology·K T KivistöP J Neuvonen
Aug 18, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·R SiekmeierW Jaross

❮ Previous
Next ❯

Citations

Jul 31, 2009·European Journal of Clinical Pharmacology·Hanna Marita SeidlingWalter Emil Haefeli
Dec 6, 2011·Archives of Pharmacal Research·Hyo-Kyung Han
Sep 26, 2002·Psychosomatics·Scott C ArmstrongElisabeth A Pimentel
Feb 8, 2011·Drug Metabolism and Pharmacokinetics·Yoshihisa Shitara
Apr 21, 2009·Uirusu·Nobuyuki Kato
Feb 5, 2008·Pharmacogenomics·Mikko Niemi
Apr 7, 2010·Expert Opinion on Drug Metabolism & Toxicology·Alice C Rodrigues
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A Ayrton, P Morgan
Aug 9, 2011·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·A García-SabinaR Martínez-Pacheco
Jul 15, 2015·Pharmaceutical Research·Manthena V VarmaAyman F El-Kattan
Sep 30, 2009·British Journal of Pharmacology·A Kalliokoski, M Niemi
Oct 27, 2006·Pharmacotherapy·Carol W HoltzmanSarah A Spinler
Apr 30, 2005·International Journal of Cardiology·Vincent Launay-VacherGilbert Deray
Dec 21, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Christopher J EndresJashvant D Unadkat
Jun 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Beth MalcomsonBettina C Schock
Jul 8, 2016·Journal of Clinical Pharmacology·Jeremiah D MomperJoseph D Ma
Jul 8, 2016·Journal of Clinical Pharmacology·Mitesh PatelMaciej J Zamek-Gliszczynski
Sep 8, 2004·Expert Review of Cardiovascular Therapy·Anders Asberg, Hallvard Holdaas
Nov 19, 2009·The Annals of Pharmacotherapy·James M BackesPatrick M Moriarty
Jun 22, 2017·Biochemical Pharmacology·Chun-Han LinChun-Jung Lin
Oct 9, 2002·Angiology·Moses Elisaf, Dimitri P Mikhailidis
Mar 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B KasiskeUNKNOWN National Kidney Foundation
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W P D LemahieuY Vanrenterghem
Jan 20, 2005·Circulation·Robert L PageJoAnn Lindenfeld
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masanori IkedaNobuyuki Kato
Nov 20, 2002·Expert Opinion on Pharmacotherapy·J M Lawrence, J P D Reckless
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·James K KirklinDavid C McGiffin
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Joseph Nogueira, Matthew Weir
Nov 5, 2010·American Journal of Therapeutics·Najindra MaharjanSandeep Khosla
Nov 25, 2011·Expert Review of Clinical Pharmacology·Anna KoenenHenriette E Meyer zu Schwabedissen
Mar 3, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yi-An BiYurong Lai
Nov 24, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jonathan Wagner, Susan M Abdel-Rahman
Aug 24, 2019·The Annals of Pharmacotherapy·Daniel R Migliozzi, Nicole J Asal
Oct 24, 2018·Pharmaceutical Research·Leslie Z BenetJasleen K Sodhi
Apr 22, 2021·Clinical Pharmacology and Therapeutics·Yue XiangLeslie Z Benet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.