Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers

British Journal of Clinical Pharmacology
P Talke, Brian J Anderson

Abstract

Alpha-2 agonists are direct peripheral vasoconstrictors, which achieve these effects by activating vascular smooth muscle alpha-2 adrenoceptors. The impact of this response during dexmedetomidine infusion remains poorly quantified. Our goal was to investigate the pharmacokinetic (PK) and pharmacodynamic (PD, vasoconstriction) effects of a computer-controlled dexmedetomidine infusion in healthy volunteers. After local ethics committee approval, we studied 10 healthy volunteers. To study the peripheral vasoconstrictive effect of dexmedetomidine without concurrent sympatholytic effects, sympathetic fibres were blocked with a brachial plexus block. Volunteers received a dexmedetomidine target-controlled infusion for 15 min, to a target concentration of 0.3 ng ml-1 . Arterial blood samples were collected during and for 60 min after dexmedetomidine infusion for PK analysis. Peripheral vasoconstriction (PD) was assessed using finger photoelectric plethysmography. PK/PD analysis was carried out using nonlinear mixed-effect models. We found that the computer-controlled infusion pump delivered mean concentrations greater than 0.3 ng ml-1 over the 15-min infusion duration. The peripheral vasoconstrictive effect correlated with dexmedetomi...Continue Reading

References

Jul 1, 1989·Clinical Pharmacology and Therapeutics·A KallioH Scheinin
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P B Timmermans, P A van Zwieten
May 1, 1995·Canadian Journal of Physiology and Pharmacology·D B BylundR R Ruffolo
May 1, 1996·Clinical Pharmacokinetics·N H Holford
Sep 27, 2000·Anesthesia and Analgesia·P O TalkeT Heier
Mar 6, 2004·Journal of Pharmacokinetics and Pharmacodynamics·Liping ZhangLewis B Sheiner
Mar 6, 2004·Journal of Pharmacokinetics and Pharmacodynamics·Liping ZhangLewis B Sheinerz
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Jan 17, 2008·Journal of Pharmacokinetics and Pharmacodynamics·Teun M PostMeindert Danhof
Mar 27, 2010·Paediatric Anaesthesia·Amanda L PottsGuy R Warman
Apr 24, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Marcus A BjörnssonUlrika S H Simonsson
Jan 21, 2017·Clinical Pharmacokinetics·Maud A S WeerinkPieter Colin
Aug 18, 2017·Journal of Clinical Pharmacology·April M Barbour, Michael J Fossler
Oct 22, 2017·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators

❮ Previous
Next ❯

Citations

Jul 18, 2019·European Journal of Clinical Pharmacology·Sven C van DijkmanOscar Della Pasqua
Sep 29, 2020·Anesthesiology·Shubham ChamadiaOluwaseun Akeju
May 3, 2019·Current Opinion in Anaesthesiology·James D MorseBrian J Anderson
Nov 1, 2020·Journal of Clinical Medicine·James D MorseBrian J Anderson
Jan 8, 2021·Fluids and Barriers of the CNS·Burhan O OzturkHedok Lee
Apr 9, 2021·Frontiers in Neurology·Shane Musick, Anthony Alberico
Jun 5, 2021·Paediatric Anaesthesia·James D MorseBrian J Anderson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.