Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease

Nanomedicine : Nanotechnology, Biology, and Medicine
Vinay SridharSarika Wairkar

Abstract

Selegiline, a well-known anti-Parkinson agent, is reported to be associated with poor oral bioavailability and safety. Therefore, we formulated selegiline as chitosan nanoparticles and evaluated its pharmacokinetics and pharmacodynamics after intranasal administration to rats relative to those after oral administration. The optimized formulation exhibited spherical nanoparticles with more than 90% drug loading and steady in vitro and ex vivo drug release. Selegiline concentrations in the brain and plasma were 20- and 12-fold higher, respectively, after intranasal administration than after oral administration. Treatment with intranasal nanoparticles was also associated with better performance in locomotor activity, catalepsy, and stride length tests and significantly increased dopamine, catalase activity, and glutathione content in the brain. Therefore, intranasally administered selegiline nanoparticles holds superior therapeutic value compared to oral administration and can be a promising approach for the treatment of Parkinson's disease.

Citations

Mar 1, 2019·Pharmaceutics·Daniel Mihai TeleanuRaluca Ioana Teleanu
Oct 31, 2019·Expert Opinion on Drug Delivery·Saleha RehmanJaved Ali
May 21, 2020·Frontiers in Bioengineering and Biotechnology·Doddy Denise Ojeda-HernándezJuan C Mateos-Díaz
Nov 30, 2018·Journal of Clinical Medicine·Daniel Mihai TeleanuRaluca Ioana Teleanu
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianghua LiGuangli Yu
Nov 4, 2020·Journal of Neurology·Jonathan BaskinSimon J G Lewis
Mar 4, 2021·Neurochemistry International·Uma Maheswari Krishnan
Aug 10, 2021·International Journal of Pharmaceutics·Qing-Hua LanQing Yao
Aug 28, 2021·International Journal of Molecular Sciences·Shiran SuDavid L Brody
Sep 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thuy Trang NguyenGiau Van Vo
Nov 27, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Pallavi KiranRohit Srivastava

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