Pharmacokinetics and pharmacodynamics of intravenous and transdermal flunixin meglumine in meat goats

Journal of Veterinary Pharmacology and Therapeutics
Emily J ReppertJohann F Coetzee

Abstract

The aim of this study was to determine the pharmacokinetics and prostaglandin E2 (PGE2 ) synthesis inhibiting effects of intravenous (IV) and transdermal (TD) flunixin meglumine in eight adult female Boer goats. A dose of 2.2 mg/kg was administered intravenously (IV) and 3.3 mg/kg administered TD using a cross-over design. Plasma flunixin concentrations were measured by LC-MS/MS. Prostaglandin E2 concentrations were determined using a commercially available ELISA. Pharmacokinetic (PK) analysis was performed using noncompartmental methods. Plasma PGE2 concentrations decreased after flunixin meglumine for both routes of administration. Mean λz -HL after IV administration was 6.032 hr (range 4.735-9.244 hr) resulting from a mean Vz of 584.1 ml/kg (range, 357.1-1,092 ml/kg) and plasma clearance of 67.11 ml kg-1  hr-1 (range, 45.57-82.35 ml kg-1  hr-1 ). The mean Cmax , Tmax, and λz -HL for flunixin following TD administration was 0.134 μg/ml (range, 0.050-0.188 μg/ml), 11.41 hr (range, 6.00-36.00 hr), and 43.12 hr (15.98-62.49 hr), respectively. The mean bioavailability for TD flunixin was calculated as 24.76%. The mean 80% inhibitory concentration (IC80 ) of PGE2 by flunixin meglumine was 0.28 μg/ml (range, 0.08-0.69 μg/ml) and wa...Continue Reading

References

Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Dec 22, 1999·Veterinary Research Communications·M AlvinerieC Chartier
May 18, 2001·Parasitology Research·J DupuyM Alvinerie
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Dec 18, 2014·Journal of the American Veterinary Medical Association·Lindsey W KissellGeof W Smith
Nov 3, 2016·Journal of Veterinary Pharmacology and Therapeutics·M D KleinhenzJ F Coetzee

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Citations

Jul 30, 2019·Journal of Veterinary Pharmacology and Therapeutics·Emily J ReppertJohann F Coetzee
Sep 11, 2020·Veterinary Medicine International·Gregory ScottLarry J Minter
Feb 6, 2021·The Veterinary Clinics of North America. Food Animal Practice·Joe S SmithPaul Plummer
Jun 27, 2021·Journal of Veterinary Pharmacology and Therapeutics·Heather K KnychPhilip H Kass

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