Pharmacokinetics and pharmacogenomics in esophageal cancer chemoradiotherapy

Advanced Drug Delivery Reviews
Toshiyuki SakaedaKohshi Nishiguchi

Abstract

Esophageal cancer is one of the most lethal malignancies. Surgical resection of the tumor from the primary site has been the standard treatment, especially for localized squamous cell carcinoma, but considerable clinical efforts during the last decade have resulted in novel courses of treatment. These options include chemoradiotherapy, consisting of a continuous infusion of 5-fluorouracil (5-FU), cisplatin (CDDP), and concurrent radiation. Given the substantial inter- and/or intra-individual variation in clinical outcome, future improvements will likely require the incorporation of a novel anticancer drug, pharmacokinetically guided administration of CDDP or 5-FU, and identification of potential responders by patient genetic profiling prior to treatment. In this review, the latest information on incidence, risk factors, biomarkers, therapeutic strategies, and the pharmacokinetically guided or genotype-guided administration of CDDP and 5-FU is summarized for future individualization of esophageal cancer treatment.

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Citations

Oct 28, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shinji KobuchiToshiyuki Sakaeda
May 29, 2009·Medical Hypotheses·Siamak Hajizadeh Farkoush, Siamak Najarian
Oct 24, 2014·Biomedical Chromatography : BMC·Yi-Sheng HeChun-Su Yuan
Mar 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jinping QiaoWeidong Lu
Oct 25, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Lixia YuanMin Zhang
Jul 28, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ivan Ho Yuen PunJohnny Cheuk On Tang
Nov 28, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Shinji KobuchiToshiyuki Sakaeda

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