Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Desmond Y H YapTak Mao Chan

Abstract

There is little data on mycophenolic acid (MPA) pharmacokinetics and pharmacogenomics and optimal MPA exposure in lupus nephritis (LN) patients during long-term maintenance. We measured blood MPA levels at 1, 2, 4, 8, 10 and 12-h post-dose (i.e. C1, C2, C4, C8, C10 and C12) in 88 stable LN patients receiving maintenance prednisolone and mycophenolate mofetil, repeated every 6 months. The relationship between MPA exposure and single nucleotide polymorphisms (SNPs) of adenosine triphosphate-binding cassette subfamily C member 2 (ABCC2; rs2273697, rs3740066, rs717620 and rs17222723), organic anion-transporting polypeptides (OATPs; rs7311358 and rs4149117) and uridine diphosphate glucuronosyltransferase (UGT; rs17863762, rs6714486, rs17868320 and rs72551330) was also investigated. C1, C2 and C12 were 8.3 ± 6.6 , 7.2 ± 5.2 and 2.0 ± 1.4 mg/L and all correlated with the 12-h area under the curve (AUC0-12; r = 0.51, 0.85 and 0.73; P = 0.02, <0.001 and <0.001, respectively). C12 inversely correlated with hemoglobin, immunoglobulins and leukocyte levels (P < 0.05 for all). Five renal flares, 11 episodes of infection and 10 episodes of anemia (hemoglobin <10 g/dL) occurred over 96 weeks, with a corresponding C12 of 1.3 ± 0.5, 4.3 ± 2.6 a...Continue Reading

References

Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Tak-Mao ChanUNKNOWN Hong Kong Nephrology Study Group
Sep 24, 2005·Clinical Pharmacokinetics·Reinier M van HestRon A A Mathot
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R BorrowsD Taube
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y Le MeurP Marquet
May 1, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Josep GrinyóLaurent Essioux
Jul 1, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Irmgard NeumannJosef Kovarik
Apr 17, 2009·Journal of the American Society of Nephrology : JASN·Gerald B AppelUNKNOWN Aspreva Lupus Management Study Group
Jun 10, 2010·Kidney International·Paungpaga LertdumronglukYingyos Avihingsanon
Sep 14, 2010·Annals of the Rheumatic Diseases·Frédéric A HoussiauUNKNOWN MAINTAIN Nephritis Trial Group
Oct 16, 2010·Lupus·E Osio-Salido, H Manapat-Reyes
Mar 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Nicolas Picard, Pierre Marquet
Apr 19, 2011·The Journal of Rheumatology·Katerina LaskariHaralampos M Moutsopoulos
Nov 18, 2011·The New England Journal of Medicine·Mary Anne DooleyUNKNOWN ALMS Group
Mar 30, 2012·International Journal of Clinical Pharmacology and Therapeutics·Baralee PunyawudhoSomratai Vadcharavivad
May 5, 2012·Arthritis Care & Research·Bevra H HahnUNKNOWN American College of Rheumatology
Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Jul 24, 2013·Nephrology·Chi Chiu MokUNKNOWN Asian Lupus Nephritis Network (ALNN)
May 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Teun van GelderStefan P Berger
Jun 26, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Pengmei LiTeun van Gelder
Dec 24, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Donal J SextonRobert N Foley
Mar 12, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Teun van Gelder, Dennis A Hesselink
Jul 3, 2017·The Journal of Rheumatology·Desmond Y H YapTak Mao Chan

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Citations

Jul 31, 2019·Clinical Science·Chenzhu ZhangTak Mao Chan
Jan 19, 2021·Expert Opinion on Drug Metabolism & Toxicology·Henrike Bruckmueller, Ingolf Cascorbi
Mar 21, 2021·Current Opinion in Rheumatology·Katherine ChakrabartiW Joseph McCune

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