Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women

American Journal of Obstetrics and Gynecology
Kathleen F BrookfieldB Carvalho

Abstract

Magnesium sulfate is one of the most commonly prescribed intravenous medications in obstetrics. Despite its widespread use, there are limited data about magnesium pharmacokinetics, and magnesium is prescribed empirically without dose adjustment for different indications. The aim of this study was to characterize the pharmacokinetics and placental transfer of magnesium sulfate in pregnant women and to determine key covariates that impact the pharmacokinetics. This is a prospective pharmacokinetic cohort study of pregnant women who were prescribed magnesium sulfate for preeclampsia, preterm labor, or extreme prematurity. Women received a 4-g loading dose and 2 g/h maintenance dose as clinically indicated. Maternal blood samples were obtained before and at multiple time points during and after magnesium administration. Cord blood also was sampled at delivery. A population pharmacokinetic approach that used a nonlinear mixed-effects modeling was used to characterize magnesium disposition. Pharmacokinetic profiles of 111 pregnant women were analyzed. Magnesium clearance was 3.98 L/h in preeclamptic women and 5.88 L/h non-preeclamptic women. Steady-state concentration of magnesium was 7.2 mg/dL in preeclamptic women compared with 5.1...Continue Reading

References

May 1, 1977·Clinical Pharmacokinetics·B Krauer, F Krauer
Nov 3, 1988·The New England Journal of Medicine·R S Goldman, S M Finkbeiner
May 1, 1983·American Journal of Obstetrics and Gynecology·K W GreenR Resnik
Feb 1, 1982·The Journal of Pediatrics·D K RaschR Reddi
Sep 25, 2001·American Journal of Obstetrics and Gynecology·F S ChuanR L Rasiah
Oct 24, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Vedat DayiciogluMehmet Kucukbas
Dec 4, 2003·JAMA : the Journal of the American Medical Association·Caroline A CrowtherUNKNOWN Australasian Collaborative Trial of Magnesium Sulphate (ACTOMg SO4) Collaborative Group
Apr 21, 2004·The Journal of Clinical Psychiatry·Stephen M Stahl
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Robert Mittendorf, Peter G Pryde
Dec 2, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·R MittendorfK-S Lee
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Arundhathi Jeyabalan, Kirk P Conrad
Feb 23, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·T del moralE Bancalari
Aug 30, 2008·The New England Journal of Medicine·Dwight J RouseUNKNOWN Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network
Mar 17, 2010·Early Human Development·Koji YokoyamaMariko Y Momoi
May 28, 2010·Acta Obstetricia Et Gynecologica Scandinavica·Mahmoud ShokryHosam Abozid
Mar 8, 2011·American Journal of Obstetrics and Gynecology·Mara B GreenbergDeirdre J Lyell
Jan 25, 2013·Obstetrics and Gynecology·Carmen M TudelaJames M Alexander
Mar 28, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·D H SalingerT Easterling
Aug 24, 2013·Obstetrics and Gynecology·Joy K Anderson, Curtis Boyd
Sep 10, 2014·Obstetrics and Gynecology·Jessica A McPhersonDavid M Stamilio
Nov 26, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·B O OkusanyaA M Gülmezoglu

❮ Previous
Next ❯

Citations

Jun 15, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jarunee LeetheeragulTuangsit Wataganara
Feb 13, 2019·Current Opinion in Obstetrics & Gynecology·Kathleen F Brookfield, Abigail Vinson
Oct 17, 2018·Neural Regeneration Research·Clément Chollat, Stéphane Marret
Mar 1, 2019·Journal of Obstetrics and Gynaecology of India·Arun AmbadkarAnahita R Chauhan
May 2, 2018·Frontiers in Neurology·Clément ChollatStéphane Marret
Jul 10, 2020·Drugs in R&D·Tatiana Xavier da CostaAntonio Gouveia Oliveira
Nov 7, 2020·Obstetrics and Gynecology·Kathleen F BrookfieldBrendan Carvalho
Oct 3, 2020·American Journal of Obstetrics and Gynecology·Agustin Conde-AgudeloÁngel José Garcia Sánchez
Aug 20, 2021·European Journal of Pharmacology·Hossein RezazadehNepton Soltani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Gynaecologia. International Monthly Review of Obstetrics and Gynecology. Revue Internationale Mensuelle D'obstétrique Et De Gynécologie. Monatsschrift Für Geburtshilfe Und Gynäkologie
E Neumayer, K H Stark
© 2022 Meta ULC. All rights reserved