PMID: 6145279Apr 1, 1984

Pharmacokinetics and placental transmission of fazadinium in elective caesarean sections

Acta Anaesthesiologica Scandinavica
M P RainaldiS Boschi

Abstract

The pharmacokinetics and placental transmission of fazadinium (0.75-0.80 mg kg-1) were studied in seven pregnant women undergoing elective caesarean section. Plasma levels of the drug were determined by a spectrofluorimetric method and pharmacokinetics were derived according to a 2-compartment open model. Distribution and elimination half-lives averaged 0.07 +/- 0.03 (t1/2 alpha) and 1.24 +/- 0.34 (t1/2 beta) h; the volume of distribution was 20.75 +/- 5.81 1, and the plasma clearance was 202.33 +/- 39.2 ml min-1 1.73 m2. The ratio between umbilical venous blood and maternal blood at delivery ranged from 2.57 to 17.5%. Urinary elimination accounted for 37% of the injected dose within 24 h. It is concluded that because of early good intubating conditions and favourable pharmacokinetics with a modest placental passage, fazadinium might be particularly useful in obstetrics.

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·P DuvaldestinJ M Desmonts
Aug 1, 1978·British Journal of Anaesthesia·P DuvaldestinJ M Desmonts
Oct 1, 1979·British Journal of Anaesthesia·P DuvaldestinJ M Desmonts
Feb 1, 1978·Anaesthesia and Intensive Care·I M RamzanE J Triggs
Jan 1, 1975·Anaesthesia·C E BloggJ A Bell
Nov 1, 1973·British Journal of Anaesthesia·J DrábkováE van der Kleijn
Aug 1, 1980·British Journal of Anaesthesia·P DuvaldestinG Saumon
Apr 1, 1954·American Journal of Obstetrics and Gynecology·J Q ADAMS
Apr 1, 1956·British Journal of Anaesthesia·J S CRAWFORDJ E GARDINER
May 1, 1955·The American Journal of Physiology·L A SAPIRSTEING HANUSEK

Citations

Jan 1, 1991·Pediatric Radiology·L PierroR Brancato

Related Concepts

Anesthesia, Intravenous
Paracervical Block
Postcesarean Section
Half-Life
Maternal-Fetal Exchange
Pyridinium Compounds

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