PMID: 11897977Mar 19, 2002Paper

Pharmacokinetics and protein binding of mycophenolic acid in stable lung transplant recipients

Therapeutic Drug Monitoring
Mary H H EnsomRobert D Levy

Abstract

Mycophenolate mofetil (MMF) use is increasing in solid organ transplantation. Mycophenolic acid (MPA), the active metabolite of MMF, is highly protein bound and only free MPA is pharmacologically active. The average MPA free fraction in healthy adult individuals, stable renal transplant recipients, and heart transplant recipients is approximately 2 to 3%. However, no data are currently available on MPA protein binding in stable lung transplant recipients and little is known regarding MPA's pharmacokinetic characteristics after lung transplantation. The purpose of this study was to characterize the pharmacokinetic profile and protein binding of MPA in this patient population. Seven patients were entered into the study. On administration of a steady-state morning MMF dose, blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 8, 9, 10, and 12 hours post-dose. Total MPA concentrations were measured by a validated HPLC method with UV detection and followed by ultrafiltration of pooled samples for free MPA concentrations. Area under the curve (AUC), peak concentration (Cmax), time to peak concentration (Tmax), trough concentration (Cmin), free fraction (f), and free MPA AUC were calculated by traditional pharmacokinetic methods. Pati...Continue Reading

References

May 23, 1998·Advances in Experimental Medicine and Biology·G SeebacherM M Müller
Jul 1, 1998·Clinical Pharmacokinetics·R E BullinghamB R Kamm
Aug 29, 1998·Clinical Biochemistry·L M ShawK L Brayman
Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B M MeiserB Reichart
Jul 7, 1999·Journal of Clinical Pharmacology·B KaplanL M Shaw
Feb 21, 2002·Critical Care Nursing Quarterly·P G Cuddy

❮ Previous
Next ❯

Citations

Dec 17, 2004·Journal of Clinical Pharmacology·Jaya PisupatiRaman Venkataramanan
Jan 5, 2007·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Aug 21, 2009·Clinical Pharmacokinetics·Caroline Monchaud, Pierre Marquet
Aug 27, 2009·Clinical Pharmacokinetics·Caroline Monchaud, Pierre Marquet
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Maria ShipkovaEberhard Wieland
Mar 14, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xavier CussonneauRoselyne Boulieu
Jun 17, 2004·Journal of Clinical Pharmacology·Eun Kyung ChoJung Mi Oh
Nov 25, 2003·The Annals of Pharmacotherapy·Mary H H EnsomRobert D Levy
Aug 3, 2006·The Annals of Pharmacotherapy·Lillian S L TingMary H H Ensom
Feb 17, 2007·Therapeutic Drug Monitoring·Lillian S L TingMary H H Ensom
Jun 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Olivier BernardChantal Guillemette
Sep 20, 2020·Clinical Transplantation·Hiroshi YabukiYoshinori Okada
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Olivier Bernard, Chantal Guillemette

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
S MorgeraH H Neumayer
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Miyoko NaganumaHiroshi Kasanuki
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M BaraldoM Furlanut
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
John E RayAndrew J McLachlan
© 2022 Meta ULC. All rights reserved